Epilepsy clinical trials recruiting in Canada

Clinical Outcomes of Pregnant Individuals With Epilepsy - Prospective Study

Recruiting now1 site

The aim of this study is to investigate the pregnancy, delivery, neonatal, and epilepsy outcomes in individuals with epilepsy undergoing pregnancy at the Maternal and Infant Health Programs at the University Health Network - Sinai Health an…

Deep Brain Stimulation vs. Vagus Nerve Stimulation for Epileptic Spasms

Opening soon1 site

Deep Brain Stimulation vs. Vagus Nerve Stimulation for the Treatment of Drug-Resistant Epilepsy and Epileptic Spasms in Children: A Randomized Control Trial

Enhanced MRI Imaging in Healthy Participants and Participants With Epilepsy

Recruiting nowPhase 21 site

Temporal lobe epilepsy (TLE) is a common type of epilepsy and one of the most likely to not be controlled by medication. For patients who do not respond to medication, surgery can result in a cure of seizures. Given the fact that around 50%…

Using Micro-filaments to Detect "fast Ripples" and Improve the Identification of the Epileptogenic Zone

Recruiting now1 site

record fast ripples with novel intracranial electrodes with micro-tetrodes to improve the identification of epileptogenic zone (EZ) and investigate the neuronal circuits underlying brain dynamics associated with epilepsy

Lemborexant Treatment of Insomnia Linked to Epilepsy

Recruiting nowPhase 32 sites

The goal of this clinical trial is to assess whether Lemborexant can improve sleep in patients with epilepsy.

Seizure Recurrence After Unprovoked First Seizure

Recruiting now2 sites

One in 10 people have a seizure during their life. Usually no cause is identified. Seizures without an identified cause are called unprovoked first seizure (UFS). Most people with UFS do not have further seizures. Being able to predict the …

The Lullaby Project as a Musical Intervention for Pregnant Individuals With Epilepsy

Recruiting now1 site

This study's proposed intervention is the randomized participation of pregnant individuals with epilepsy in the Lullaby Project coordinated by a musical institution in Toronto. The purpose of this present study is to investigate the potenti…

Real World Evidence on the Use of Medical Cannabis in Pediatrics

Recruiting now1 site

CAN-RWE is an observational study that is following 500 children who have authorizations for medical cannabis for two years from across Canada.

Real-World Evidence in Patient-Reported Outcomes for Medical Cannabis (MC-RWE)

Recruiting now1 site

This prospective observational study aims to describe the effectiveness of MC on pain, epilepsy, sleep and /or anxiety/depression in a cohorts of patients authorized to use MC, using pre-defined, validated self assessment scales.

Biology of Juvenile Myoclonic Epilepsy

Recruiting now15 sites

The investigators are collecting genetic information through blood samples as well as clinical and EEG data from over 1000 people with Juvenile Myoclonic Epilepsy (JME) across the UK, Europe and North America. This study will draw on both e…

The Genetics Navigator: Evaluating a Digital Platform for Genomics Health Services

Recruiting now3 sites

Genetic testing (GT) (including targeted panels, exome and genome sequencing) is increasingly being used for patient care as it improves diagnosis and health outcomes. In spite of these benefits, genetic testing is a complex and costly heal…

A Study to Investigate the Transition of Children From 'Artisanal" Cannabidiol (CBD) to Epidiolex

Opening soonPhase 41 site

The goal of this clinical trial is to learn the best way to switch children with Lennox-Gastaut Syndrome (LGS) or Dravet Syndrome (DS) taking 'artisanal' (non pharmaceutical-grade) cannabidiol (CBD) to Epidiolex for treatment of seizures. T…

LIFUS For Neurological Disorders

Recruiting now1 site

Low intensity focused ultrasound (LIFUS) has the potential to be used as a means of non-invasive neuro-modulation. To this day, the use of LIFUS is under investigation. Studies in healthy subjects have shown that application of LIFUS to the…

ASCEND: Safety and Tolerability of ION337 for the Treatment of Dravet Syndrome

Recruiting nowPhase 1/26 sites

The primary purpose of this study is to evaluate the safety and tolerability of ION337 in participants with Dravet syndrome (DS).

A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome

Recruiting nowPhase 369 sites

This is a multicenter, Phase 3, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of clemizole hydrochloride (EPX-100) as adjunctive therapy in children and adult participants with Dravet syndro…

A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures

Recruiting nowPhase 3138 sites

This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the clinical efficacy, safety, and tolerability of XEN1101 administered as adjunctive treatment in primary generalized tonic-clonic seizures (PGT…

A Phase 3, Placebo-Controlled Study to Investigate LP352 in Children and Adults With Dravet Syndrome (DS)

Recruiting nowPhase 3104 sites

This (DEEp SEA Study) is a double-blind, randomized, placebo-controlled, multicenter study to investigate the efficacy, safety, and tolerability of LP352 in the treatment of seizures in children and adults with DS. The study consists of 3 m…

COMparison Between Anakinra and Tocilizumab in NORSE - "COMBAT-NORSE"

Opening soonPhase 333 sites

The goal of this clinical trial is to find out whether two existing medications-anakinra and tocilizumab-can effectively treat a rare and life-threatening brain condition called NORSE (New-Onset Refractory Status Epilepticus). NORSE causes …

North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)

Recruiting now17 sites

The North American Mitochondrial Disease Consortium (NAMDC) maintains a patient contact registry and tissue biorepository for patients with mitochondrial disorders.

Common questions

How do I find a epilepsy clinical trial near me in Canada?

Use Beacon's free search: enter "epilepsy", your age, and your location, and you'll see recruiting trials sorted by distance, each explained in plain language — including sites just across the US border. Beacon searches the full official registry and never requires an account.

Does joining a clinical trial cost money?

The study treatment and study-related tests are usually provided at no cost, and some trials help with travel. In Canada, your provincial health coverage continues to apply to your routine care — always confirm details with the study team.

Can I leave a clinical trial after joining?

Yes. Participation is always voluntary, and you can leave a trial at any time, for any reason, without losing your normal medical care.

Do I qualify for these trials?

Every trial has its own eligibility criteria. Beacon translates each trial's criteria into a plain-language checklist you can review and bring to your doctor — only the study team can confirm whether you qualify.