Dominantly Inherited Alzheimer Network (DIAN)

What this study is about

The purpose of this study is to identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.

Who can join (things the study team will check)

✅ You may be able to join if…

• Written informed consent obtained from participant and collateral source prior to any study-related procedures.
• Aged 18 (inclusive) or older and the child of an affected individual (clinically or by testing) in a pedigree with a known mutation for ADAD.
• Cognitively normal to very mild or mild cognitive impairment (CDR score range 0-1.0). Primary enrollment will focus on the recruitment of asymptomatic adult children who are more than 15 years younger than the estimated age of symptom onset. Enrollment of new participants with moderate cognitive impairment is allowed with the prior approval of the DIAN Coordinating Center.
• Has two persons who are not their full-blooded siblings who can serve as collateral sources for the study.
• Fluent in a language approved by the DIAN Coordinating Center at about the 6th grade level (international equivalent) or above.

🚫 You may not be able to join if…

• Under age 18
• Medical or psychiatric illness that would interfere in completing initial and follow-up visits
• Requires nursing home level care
• Has no one who can serve as a study informant

Where this trial is running

• Mayo Clinic Jacksonville, Jacksonville, Florida, United States
• Indiana University-Indiana Alzheimer Disease Center, Indianapolis, Indiana, United States
• Brigham and Women's Hospital, Boston, Massachusetts, United States
• Washington University in St. Louis School of Medicine, St Louis, Missouri, United States
• Columbia University, New York, New York, United States
• University of Pittsburgh, Pittsburgh, Pennsylvania, United States
• Butler Hospital, Providence, Rhode Island, United States
• University of Washington, Seattle, Washington, United States
• Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (FLENI), Salta, Salta Province, Argentina
• Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia" (FLENI) Instituto de Investigaciones Neurológicas Raúl Correa, Buenos Aires, Argentina
• Neuroscience Research Australia, Sydney, New South Wales, Australia
• Mental Health Research Institute, University of Melbourne, Melbourne, Victoria, Australia

+ 14 more sites.

Who to contact

Alisha Daniels, MD,MHA · (314) 273-9057

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT00869817.