Allogeneic Stem Cell Transplantation for Children and Adolescents With Acute Lymphoblastic Leukaemia

What this study is about

The ALL SCTped 2012 FORUM is a multinational, multi-centre, controlled, prospective phase III study for the therapy and therapy optimisation for children and adolescents with ALL in complete morphological remission (CR, less than 5% bone marrow blasts, no blasts in cerebrospinal fluid, no other extramedullary leukemia), who have an indication for HSCT with a myeloablative conditioning regimen. The stratification of patients in first and following remissions according to the individual transplantation modalities rests upon an indication for allogeneic HSCT and the availability of a suitable donor within the individual transplantation groups.

Who can join (things the study team will check)

✅ You may be able to join if…

• age at diagnosis ≤ 18 years. Age at HSCT ≤ 21 years
• indication for allogeneic HSCT
• complete remission (CR) before HSCT
• written consent of the parents (legal guardian) and, if necessary, the minor patient via "Informed Consent Form"
• no pregnancy
• no secondary malignancy
• no previous HSCT
• HSCT is performed in a study participating centre

🚫 You may not be able to join if…

• patients who do not fulfil the inclusion criteria
• Non Hodgkin-Lymphoma
• the whole protocol or essential parts are declined either by patient himself/herself or the respective legal guardian
• no consent is given for saving and propagation of anonymous medical data for study reasons
• severe concomitant disease that does not allow treatment according to the protocol at the investigator's discretion (e.g. malformation syndromes, cardiac malformations, metabolic disorders)
• Karnofsky / Lansky score < 50%
• subjects unwilling or unable to comply with the study procedures

Where this trial is running

• Hospital de Pediatria "Juan P. Garrahan" Combate de Los Pozos N°1800 CABA, Buenos Aires, Argentina
• Hospital Sor Maria Ludovica, Department Hematology Stem Cell Transplant Unit, La Plata, Argentina
• Children's Cancer Centre The Royal Children's Hospital, Melbourne, Australia
• Princess Margaret Hospital for Children, Perth, Australia
• Sydney Children's Hospital, Randwick, Australia
• Lady Cilento Children's Hospital, South Brisbane, Australia
• The Children's Hospital at Westmead Oncology Unit, Sydney, Australia
• Universitätsklinik für Kinder- und Jugendheilkunde, Abt. f. Hämato-Onkologie, Graz, Austria
• Universitätsklinik für Kinder- und Jugendheilkunde, Innsbruck, Austria
• St. Anna Children's Hospital, Vienna, Austria, Vienna, Austria
• Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus
• Hôpital Universitaire des Enfants Reine Fabiola (HUDERF), Brussels, Belgium

+ 107 more sites.

Who to contact

Christina Peters, Prof. MD PhD · +43140170 · christina.peters@stanna.at

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT01949129.