JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer
Recruiting now Phase 3 NCT02468024
Run by University of Texas Southwestern Medical Center · for 18 and older · All sexes
What this study is about
To Determine if SAbR improves survival over SR in High Risk Operable Stage I NSCLC
Who can join (things the study team will check)
1.0 Inclusion Criteria 1.1 Age \> 18 years. 1.2 ECOG/Zubrod performance status (PS) 0, 1, or 2 (reference Appendix C). 1.3 Radiographic findings consistent with non-small cell lung cancer, including lesions with ground glass opacities with a solid component of 50% or greater. 1.4 The primary tumor in the lung must be biopsy confirmed non-small cell lung cancer within 180 days prior to randomization. 1.5 Tumor ≤ 4 cm maximum diameter, including clinical stage IA and selected IB by PET or PET integrated with a simultaneous CT scan (PET-CT) of the chest and upper abdomen performed within 180 days prior to randomization (reference Appendix A \& B). Repeat imaging within 90 days prior to randomization is recommended for re-staging but is not required based on institutional norms. 1.6 All clinically suspicious mediastinal N1, N2, or N3 lymph nodes (\> 1 cm short-axis dimension on CT scan and/or positive on PET scan) confirmed negative for involvement with NSCLC by one of the following methods: mediastinoscopy, anterior mediastinotomy, EUS/EBUS guided needle aspiration, CT-guided, video-assisted thoracoscopic or open lymph node biopsy within 180 days of randomization. 1.7 Tumor ver…
Where this trial is running
- UCSD, La Jolla, California, United States
- University of Colorado/Memorial, Aurora, Colorado, United States
- Penrose Cancer Center, Colorado Springs, Colorado, United States
- Boca Raton Regional Hospital, Boca Raton, Florida, United States
- Curtis and Elizabeth Anderson Cancer, Savannah, Georgia, United States
- University of Iowa, Iowa City, Iowa, United States
- University of Kansas Medical Center, Kansas City, Kansas, United States
- University of Kentucky Health Care, Lexington, Kentucky, United States
- University of Louisville Physicians, Louisville, Kentucky, United States
- Ochsner Medical Center, New Orleans, Louisiana, United States
- Luminis Health Research Institute, Annapolis, Maryland, United States
- University of Maryland Medical Center, Baltimore, Maryland, United States
+ 38 more sites.
Who to contact
Sarah Neufeld, MBA · 214-645-8525 · sarah.hardee@UTSouthwestern.edu
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT02468024.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.