Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol
Recruiting now Phase 4 NCT03105843
Run by Dr. Diane Lougheed · for 18 to 65 · All sexes · accepts healthy volunteers
What this study is about
The objectives of this study are to determine the sensory-mechanical responses to Eucapneic Voluntary Hyperventilation (EVH) and Mannitol in individuals with cough variant asthma (CVA) and methacholine-induced cough with normal airway sensitivity (COUGH) and compare these responses to a control group of healthy individuals without asthma or chronic cough. We hypothesize: 1. EVH and Mannitol cause dyspnea, cough, small airway obstruction with resultant dynamic hyperinflation, gas trapping and autoPEEP in individuals with CVA and COUGH, but not healthy controls. 2. The sensory-mechanical responses to both hyperosmolar challenges (EVH and Mannitol) are comparable within groups (CVA, COUGH and healthy controls).
Who can join (things the study team will check)
✅ You may be able to join if…
- Individuals aged 18-65 years of age with CVA and individuals with methacholine-induced cough but normal airway sensitivity. The following definitions will be used:
- CVA: chronic cough (≥8 weeks) is the sole or predominant symptom and positive methacholine challenge (PC20 ≤ 16 mg/mL) and history of cough responding to specific asthma treatment (such as inhaled steroid or 1 week trial of bronchodilator);
- Methacholine-induced cough but normal airway sensitivity: chronic cough (≥8 weeks) is the sole or predominant symptom and negative methacholine challenges (PC20 > 16 mg/mL).
- Individuals aged 18-65 years of age with no history of asthma or chronic cough.
🚫 You may not be able to join if…
- an exacerbation necessitating a change in medication, emergency department visit or hospitalizations within the previous 4 weeks
- inability to perform acceptable spirometry
- medical contraindications to methacholine challenge testing
- smoking history in excess of 10 pack years Note: Previous treatment with inhaled or systemic corticosteroids is not an exclusion criterion; medication use will be recorded and examined in the analysis.
Where this trial is running
- Kingston Health Sciences Centre, Kingston, Ontario, Canada
Who to contact
M. Diane Lougheed, MD, MSc · 613-548-2348 · diane.lougheed@kingstonhsc.ca
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT03105843.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.