Exercise Training in Patients With Persistent or Permanent Atrial Fibrillation

What this study is about

The main purpose of this project is to evaluate the effects of high-intensity interval training (HIIT) compared to moderate-intensity continuous exercise training (MICE) and standard care on exercise capacity and quality of life in patients with persistent or permanent atrial fibrillation. Positive findings are vitally important for these patients, given the condition's substantial morbidity, mortality and high economic costs.

Who can join (things the study team will check)

✅ You may be able to join if…

• persistent or permanent atrial fibrillation;
• rate controlled with a resting ventricular rate of equal to or less than 100 bpm;
• able to perform a symptom-limited exercise test;
• at least 40 years of age (i.e. participants must be 40 years or older);

🚫 You may not be able to join if…

• currently participating in routine exercise training (more than two times per week);
• unstable angina;
• diagnosed severe mitral or aortic stenosis;
• diagnosed hypertrophic obstructive cardiomyopathy with significant obstruction;
• pregnant, lactating or planning to become pregnant during the study period;
• unable to provide written, informed consent, or
• unwilling or unable to return for follow up at week 12.

Where this trial is running

• London Health Sciences Network, London, Ontario, Canada
• University of Ottawa Heart Insititue, Ottawa, Ontario, Canada

Who to contact

Jennifer L Reed, PhD · 613-696-7392 · jreed@ottawaheart.ca

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT03397602.