Conversion From Unresectable To Resectable Metastatic Colorectal Cancer.
Recruiting now Phase 2 NCT03401294
Run by University of Saskatchewan · for 18 to 70 · All sexes
What this study is about
Most patients with mCRC are treated with palliative chemotherapy and only a small number of patients with limited metastatic disease achieve long-term remission following metastasectomy. There is a growing need for more effective treatment in patients with liver-only mCRC to improve the rate of curative resection without compromising QOL.The current study is informed by our patient's needs. It aims to evaluate the rate of conversion therapy in patients with unresectable liver-only mCRC using the combination of FOLFOXIRI and bevacizumab and to assess the association between an early FDG-PT/CT response and other clinical and pathological biomarkers and hepatic metastasectomy.
Who can join (things the study team will check)
✅ You may be able to join if…
- Adult patients, aged between 18 and 70 years with histologically proven adenocarcinoma or poorly differentiated carcinoma of the colon and rectum with unresectable liver-only metastases and no extra-hepatic disease.
- World Health Organization (WHO) performance status of 0-1.
- No previous chemotherapy for advanced disease.
- Adequate functioning of the bone marrow, liver, and kidneys.
🚫 You may not be able to join if…
- Breastfeeding or pregnancy.
- An active second primary cancer with the exception of squamous cell carcinoma of the skin or an in situ cancer.
- Severe or uncompensated concomitant medical conditions.
Where this trial is running
- Allan Balir Cancer Center, Regina, Saskatchewan, Canada
Who to contact
Shahid Ahmed, MD, PhD · 3066552710 · shahid.ahmed@saskcancer.ca
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT03401294.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.