Comprehensive Assessment of Neurodegeneration and Dementia

What this study is about

This is a longitudinal observational study recruiting individuals between the ages of 50 and 90 with different types of dementia as well as a comparison group without cognitive deficits. Participants are/will be recruited at sites across Canada and will undergo assessments, neuroimaging, and biological sample collection.

Who can join (things the study team will check)

✅ You may be able to join if…

• Has subjective or objective cognitive impairment
• Written informed consent must be obtained and documented (from the patient or, where jurisdictions allow it, from a caregiver/family member)
• Sufficient proficiency in English or French to undertake self report and neuropsychological testing
• Geographic accessibility to the study site
• Must have a study partner who can participate as required in the protocol (provide corroborative information)
• Up to 12 years of education
• Fits into one of the following groups: Cognitively Unimpaired, Subjective Cognitive Impairment, Mild Cognitive Impairment, Vascular Mild Cognitive Impairment, Parkinson's Disease, Parkinson's Disease with Mild Cognitive Impairment

🚫 You may not be able to join if…

• The presence of other significant known chronic brain disease such as: moderate to severe chronic static leukoencephalopathy (including previous traumatic injury), multiple sclerosis, a serious developmental handicap, malignant tumors, Parkinson's disease (other than for the Parkinson's cohort), and other rarer brain illnesses
• Ongoing alcohol or drug abuse which in the opinion of the investigator may interfere with the subject's ability to comply with the study procedures
• Symptomatic stroke within the previous year
• Unable to undergo MRI scan due to medical contraindications or inability to tolerate the procedure

Where this trial is running

• University of Calgary, Calgary, Alberta, Canada
• University of Alberta Hospital, Edmonton, Alberta, Canada
• Djavad Mowafaghian Centre for Brain Health, Vancouver, British Columbia, Canada
• Island Health, Victoria, British Columbia, Canada
• Veteran's Memorial Building, Halifax, Nova Scotia, Canada
• Hamilton General Hospital, Hamilton, Ontario, Canada
• St. Joseph's Health Care London, London, Ontario, Canada
• Gait and Brain Lab, London, Ontario, Canada
• Bruyère Research Institute, Ottawa, Ontario, Canada
• Kawartha Centre, Peterborough, Ontario, Canada
• Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
• University Health Network Memory Clinic, Toronto, Ontario, Canada

+ 7 more sites.

Who to contact

Howard Chertkow, MD · 514 340 8222 · howard.chertkow@mcgill.ca

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT03402919.