Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE)
Recruiting now NCT03573089
Run by The University of Queensland · for 18 and older · All sexes
What this study is about
During end-stage kidney disease, clinical guidelines suggest reducing elevated phosphate levels in the blood. However, the effect of lowering blood phosphate levels on important patient-centred outcomes has never been tested. This trial will evaluate whether compared to high levels, lowering blood phosphate levels would reduce death or major events due to heart disease, improve physical health, and be cost-effective.
Who can join (things the study team will check)
✅ You may be able to join if…
- Age ≥45 years, or Age ≥18 years with diabetes,
- ESKD on haemodialysis or peritoneal dialysis, for at least 3 months,
- Currently prescribed at least one phosphate-lowering medication at any dose
- Able to provide informed consent
🚫 You may not be able to join if…
- Elective kidney transplantation scheduled,
- Concomitant major illness / comorbidity that may result in death in the next 6 months in the view of the treating physician,
- Participation in an interventional study that is likely to affect serum phosphate concentration.
Where this trial is running
- Royal Prince Alfred Hosptial, Camperdown, New South Wales, Australia
- Nepean Hospital, Kingswood, New South Wales, Australia
- St George Hospital, Kogarah, New South Wales, Australia
- Royal North Shore Hospital, Saint Leonards, New South Wales, Australia
- Western Sydney Renal Service, Westmead, New South Wales, Australia
- Wollongong Hospital, Wollongong, New South Wales, Australia
- Sunshine Coast University Hospital, Birtinya, Queensland, Australia
- Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia
- Princess Alexandra Hospital, Brisbane, Queensland, Australia
- Bundaberg Hospital, Bundaberg, Queensland, Australia
- Cairns Hospital, Cairns, Queensland, Australia
- Fraser Coast Renal Service, Hervey Bay, Queensland, Australia
+ 103 more sites.
Who to contact
Ron Wald · 416 867 3703 · WaldR@smh.ca
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT03573089.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.