Effectiveness of the Journey Total Knee Arthroplasty Versus Two Standard of Care Total Knee Arthroplasty Prostheses
Recruiting now NCT03895489
Run by University of Alberta · for 50 to 75 · All sexes
What this study is about
The purpose of the study is to determine if knee replacement performed using Journey II implant is different from two other standard-of-care knee replacements using Stryker and Zimmer in terms of knee movements and forces, walking patterns, pain, and function after surgery.
Who can join (things the study team will check)
✅ You may be able to join if…
- Participant has signed an approved informed consent form.
- Participant is a male or non-pregnant female and aged 50 to 75 years at the time of study device implantation.
- Participant has a diagnosis of Non-Inflammatory Degenerative Joint Disease (NIDJD).
- Participant is a candidate for a primary posterior-stabilized total knee replacement.
- Participant is willing and able to comply with postoperative scheduled clinical and radiographic evaluations and rehabilitation.
🚫 You may not be able to join if…
- Participant has a Body Mass Index (BMI) ≥ 40 kg/m2.
- Participant has a varus or valgus deformity greater than 15º or flexion contracture greater than 20º or knee flexion range of motion < 90º in either lower extremity.
- Participant has an active or suspected latent infection in or about the affected knee joint at time of study device implantation.
- Participant has received any orthopaedic surgical intervention to the lower extremities within the past 6 months or is expected to require any orthopaedic surgical intervention to the lower extremities, other than the TKA, within the next year.
- Participant requires bilateral total knee replacements, or has a history of contralateral partial or total knee replacement within the past 6 months.
- Participant has other medical conditions which limit the ability to evaluate the safety and efficacy of the device.
- Participant requires revision surgery of a previously implanted total knee replacement or knee fusion to the affected joint.
- Participant has a known sensitivity to device materials.
Where this trial is running
- Edmonton Bone and Joint Centre, Edmonton, Alberta, Canada
Who to contact
Ailar Ramadi, PhD · 780-492-6713 · Ailar.Ramadi@albertahealthservices.ca
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT03895489.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.
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