Synapse 3D With Intravascular Indocyanine Green

Recruiting now Phase 1/2 NCT03953144

Run by St. Joseph's Healthcare Hamilton · for 18 and older · All sexes

What this study is about

With the advent of CT screening for lung cancer, an increasing number of NSCLCs are being detected at very early stages, and the demand for pulmonary segmentectomy is rising rapidly. As such, there is a need to develop new surgical techniques to facilitate minimally invasive pulmonary segmentectomy, as segmentectomy may provide a number of significant advantages over lobectomy for patients presenting with early-stage lung cancer, or for patients unable to undergo a full lobectomy due to existing comorbidities. This study will provide the first case series using preoperative 3D anatomical planning (Synapse 3D) added to ICG and NIF-guided robotic segmentectomy to date and will be the first reported use of Synapse 3D-guided targeted pulmonary segmental resection in Canada. As lung cancer is the most frequently fatal cancer in North America, many thousands of patients will be able to benefit from this operation every year.

Who can join (things the study team will check)

✅ You may be able to join if…

Tumour size <3 cm
Clinical Stage 1 Non-Small Cell Lung Cancer (NSCLC)
CT-imaging confirming that the tumour is confined to one broncho-pulmonary segment, rendering the patient a candidate for segmental resection.

🚫 You may not be able to join if…

Hypersensitivity or allergy to ICG, sodium iodide, or iodine
Women who are currently pregnant or breastfeeding; or women of childbearing potential who are not currently taking adequate birth control.
Patients with clinical evidence of N1 or N2 disease on preoperative imaging
Pulmonary Function tests demonstrating Forced Expiratory Volume in 1s (FEV1) or diffusion capacity of the lung for carbon monoxide (DLCO) less than or equal to 30% of predicted.

Where this trial is running

St. Josephs Healthcare Hamilton, Hamilton, Ontario, Canada

Who to contact

Peter R. A. Malik, BHSc (Honours) · 905-522-1155 · malikpr@mcmaster.ca

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT03953144.

Open the interactive checklist for this trial →

Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.

Beacon is an information tool, not medical advice. Whether a trial is right for you is a decision for you, your doctor, and the study team. Trial details come from the official registry, ClinicalTrials.gov, and may change — always confirm with the study team. Beacon collects no data about you: this page has no cookies, no accounts, and no tracking.