The Combined Use of PRP with Lipoaspirate And/or Bone Marrow Aspirate in Osteoarthritis
Recruiting now Phase 2 NCT03984461
Run by Dr. Grant M. Pagdin · for 19 to 79 · All sexes · accepts healthy volunteers
What this study is about
To demonstrate the efficacy of the combined use of platelet-rich plasma (PRP) with lipoaspirate and/or bone marrow aspirate in osteoarthritis of major joints, and to compare the outcomes achieved using three combinations: PRP plus lipoaspirate, PRP plus bone marrow aspirate, and PRP plus both lipoaspirate and bone marrow aspirate.
Who can join (things the study team will check)
✅ You may be able to join if…
- Capable of providing written informed consent and willing and able to adhere to all protocol requirements.
- Male or female at least 19 years of age at the time of providing written informed consent.
- Evidence of OsteoArthritis in a major joint requires recent (within one year) imaging, either by x-ray or MRI. Kellgren \& Lawrence Grades 1-3 are accepted for participation.
🚫 You may not be able to join if…
- BMI > 35
- Arthroscopic surgery to the treatment joint within 12 months
- Cortisone or HA injection within the last 3 months prior to stem cell injection
- Inability to hold antiplatelet therapy according to treating provider prior to procedure
- Kellgren \& Lawrence Grade 4 Osteoarthritis
- Participants with a platelet count less than 100 x 109
- Participants with a Hemoglobin less than 100 g/L
- Participants who have an active Infection with fever and/or elevated white blood cell (WBC) count
- Participants with an active Cancer diagnosis.
- Participants with autoimmune disorders including rheumatoid arthritis and lupus.
- Women who are pregnant will be excluded due to the possibility of fetal harm associated with x-rays. Should a participant become pregnant during the study, she will be withdrawn from further treatment and imaging, but can participate in symptom follow-up. Female participants of childbearing potential will be counseled at screening about contraception and encouraged to use birth control for the duration of the study.
- Participants with allergies to lidocaine, heparin, or epinephrine.
Where this trial is running
- Pagdin Health, Kelowna, British Columbia, Canada
Who to contact
Grant Pagdin, MD · 250-717-3200 · info@pagdinhealth.com
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT03984461.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.
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