Diet Intervention Treatment for Active Ulcerative Colitis

What this study is about

The purpose of this study is to determine if a sustainable non-elemental diet can be used as a probiotic tool to alter the dysbiotic microbiome found in individuals with ulcerative colitis and thereby decrease disease activity.

Who can join (things the study team will check)

✅ You may be able to join if…

• • Females and Males between the ages of 18 - 75 years of age at the time of enrolment
  • Must have established diagnosis of UC by standard endoscopic, radiographic, or histological criteria
  • Must have active UC defined by having a Mayo score equal to or greater than 2 within two months prior to enrollment
  • Must have had > 10cm involvement at some point in their disease history
  • FCP>250 or active endo within 6 months
  • If a smoker, must not change smoking habits (frequency) during the course of the study
  • If receiving medical therapy, no baseline therapy change within 4 weeks of study initiation and no change during the course of the study

🚫 You may not be able to join if…

• • Uncontrolled inflammation which will likely require surgery or escalation of therapy within 4 weeks of enrollment
  • Pregnant or lactating females
  • Allergy or intolerance to key or a great number food components of the study diet
  • Current NSAID use
  • Diagnosed with PSC
  • Using topical therapies or suppositories
  • Antibiotic use within 4 weeks of the study enrollment or during the study
  • Confirmed C. difficile infection within 3 months of recruitment;
  • Diagnosis of primary PSC;
  • Currently using topical therapies or suppositories
  • History of dysplasia or colorectal neoplasia.

Where this trial is running

• Mount Sinai Hospital, Toronto, Ontario, Canada

Who to contact

Jenny Lee · 4165864800 · jenny.lee@sinaihealth.ca

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT04121806.