Breathing-Maneuver-Induced Myocardial Oxygenation Reserve Validated by FFR (B-MORE)

What this study is about

The study aims to determine a diagnostic marker for regionally impaired myocardial oxygenation response in patients with suspected coronary artery stenosis.

Who can join (things the study team will check)

✅ You may be able to join if…

• Age: > 40y
• No known current or pre-existing significant medical problems that would affect the cardiovascular or respiratory system. CAD Patients
• Age > 18 y
• Indication for invasive coronary angiography based on symptoms and a test positive for inducible coronary ischemia, or previous coronary angiography.

🚫 You may not be able to join if…

• General MRI contraindications: Pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, knowledge or suspicion of pregnancy.
• Consumption of caffeine (coffee, tea, cocoa, chocolate, "energy drink") during the 12 hours prior to the exam.
• Regular nicotine consumption during the last 6 months. Patients only
• Vasoactive medication (e.g. nitro) during the 12 hours prior to the exam Contraindications to adenosine (2nd or 3rd A-V block, sinus node disease, asthma, bronchoconstrictive diseases).
• Acute Coronary Syndrome (ACS), or previous Coronary Artery Bypass Surgery
• Previous myocardial infarction within 1 month
• Clinically unstable condition
• Significant or uncontrolled arrhythmia

Where this trial is running

• McGill University Health Center, Montreal, Quebec, Canada

Who to contact

Elizabeth Konidis · 514 934-1934 · elisavet.konidis@muhc.mcgill.ca

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT04126148.