The Sunnybrook Type 2 Diabetes Study

What this study is about

The Sunnybrook Type 2 Diabetes Study (S2DS) is a prospective observational study of people with prediabetes or Type 2 Diabetes Mellitus (T2DM), that aims to understand the aetiologies, manifestations, and clinical consequences of mood and cognitive complications. The study recruits from the services at Sunnybrook Health Sciences Centre and from the neighbouring University Health Network Toronto Rehabilitation Institute Cardiac Rehabilitation Program.

Who can join (things the study team will check)

✅ You may be able to join if…

• Have at least one of the following: high HbA1c, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), but not yet diagnosed with Type 2 diabetes or have a diagnosis of Type 2 diabetes.
• Be able to communicate in English
• Be 18 years of age or older

🚫 You may not be able to join if…

• Pregnancy
• Inability to give informed consent
• Current cancer diagnosis
• Have a prior diagnosis of bipolar disorder or schizophrenia.
• Have a prior diagnosis of a neurological and/or neurodegenerative disorder.
• Have a current substance use disorder or a previous substance use disorder diagnosed within the last 5 years (excluding nicotine)
• Poor score on the Mini Mental State Examination (MMSE)

🚫 You may not be able to join if…

• Contraindications to SHSC's MRI safety protocol.
• Participants that do not meet the inclusion/exclusion criteria of the main study.

🚫 You may not be able to join if…

• Use of medical equipment that would interfere with the placement of the CVR mask.
• Significant pulmonary disease (e.g. asthma, pulmonary fibrosis, emphysema, chronic obstructive pulmonary disease, pulmonary vascular disease, pleural disorders, pneumonia)
• Participants that do not meet the criteria for the MRI sub-study.

🚫 You may not be able to join if…

• Participants that have a medical device that would interfere with placement of portable sleep monitor equipment i.e. Participant requires O2 therapy and uses nasal prongs
• Participants that have a condition that may compromise accuracy of the HSAT results i.e. moderate-severe pulmonary disease or congestive heart failure
• Participants that do not meet the inclusion/exclusion criteria of the main study

Where this trial is running

• Sunnybrook Research Institute, Toronto, Ontario, Canada

Who to contact

Walter Swardfager, PhD · 416-480-6100 · w.swardfager@utoronto.ca

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT04455867.