Integrated Patient Avatars for Guiding Systemic Therapy Treatments in Metastatic Breast Cancer Patients
Recruiting now NCT04608357
Run by Sunnybrook Health Sciences Centre · for 18 and older · All sexes
What this study is about
The investigators propose to use clinically validated patient avatar technology ("PDXovo") that can test multiple drugs against patients' cancers to identify the most promising systemic therapy for each individual.
Who can join (things the study team will check)
✅ You may be able to join if…
- Age 18+.
- Metastatic breast cancer irrespective of subtype.
- Measurable disease as per RECIST 1.1 criteria.
- Metastatic disease involving the lymph nodes and/or visceral organs is required.
- Willingness to undergo a biopsy prior to the start of planned systemic therapy.
🚫 You may not be able to join if…
- Lack of feasibility to obtain a core biopsy of a metastatic site other than the bone (e.g. a metastatic lesion cannot be safely sampled due to proximity to vasculature).
- Inability to provide informed consent.
Where this trial is running
- Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Who to contact
Katarzyna J Jerzak, MD MSc FRCPC · 416-480-6100 · katarzyna.jerzak@sunnybrook.ca
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT04608357.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.
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