Novel Pulmonary Imaging of Lung Structure and Function in E-cigarette Smokers
Recruiting now NCT04616313
Run by Western University, Canada · for 16 and older · All sexes · accepts healthy volunteers
What this study is about
This is a longitudinal study of the long-term health impact of e-cigarette smoking on the lungs. Participants will be followed over a period of 5 years, and impacts of e-cigarette smoking on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas, pulmonary function tests, exercise capacity, computed tomography images and questionnaires.
Who can join (things the study team will check)
✅ You may be able to join if…
- Written informed consent must be directly obtained from legally competent participants before any study-related assessment is performed.
- Male and female participant age ≥16 years.
- Participant has recently started vaping, >1 and <5 years weekly use.
- 70 participants will be c-cigarette never users.
- 70 participants will be former or current c-cigarette users.
- 10 asymptomatic age and sex-matched healthy people who have never used e- or c-cigarettes will be controls.
🚫 You may not be able to join if…
- Participants with contraindications for undergoing an MRI such as participants with MRI-sensitive implants, tattoos with MRI-sensitive dye and severe claustrophobia.
- Participant is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand written material.
- Participant unable to perform spirometry or plethysmography maneuvers.
Where this trial is running
- Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre, London, Ontario, Canada
Who to contact
Grace E Parraga, PhD · 519-931-5265 · gparraga@robarts.ca
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT04616313.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.