A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes
Recruiting now Phase 3 NCT04786262
Run by Vertex Pharmaceuticals Incorporated · for 18 to 65 · All sexes
What this study is about
This study will evaluate the safety, tolerability and efficacy of VX-880 infusion in participants with Type 1 diabetes (T1D) and impaired awareness of hypoglycemia (IAH) and severe hypoglycemia.
Who can join (things the study team will check)
✅ You may be able to join if…
- Clinical history of T1D with > 5 years of duration of insulin dependence
- At least two episodes of documented severe hypoglycemia in the 12 months prior to enrollment
- Stable diabetic treatment
- Consistent use of continuous glucose monitor (CGM) for at least 3 months before Screening and willingness to use CGM for the duration of the study
Where this trial is running
- City of Hope, Duarte, California, United States
- University of California San Francisco, San Francisco, California, United States
- UHealth Diabetes Research Institute, Miami, Florida, United States
- Northwestern Organ Transplant Center, Chicago, Illinois, United States
- University of Chicago, Chicago, Illinois, United States
- Johns Hopkins University, Baltimore, Maryland, United States
- Massachusetts General Hospital, Boston, Massachusetts, United States
- Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States
- University of Pittsburgh Medical Center Montefiore, Pittsburgh, Pennsylvania, United States
- Baylor Scott and White Research Institute, Dallas, Texas, United States
- VCU Medical Center, Richmond, Richmond, Virginia, United States
- University of Wisconsin, Madison, Wisconsin, United States
+ 17 more sites.
Who to contact
Medical Information · 617-341-6777 · medicalinfo@vrtx.com
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT04786262.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.
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