Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS)
Recruiting now Phase 4 NCT05114096
Run by McMaster University · for 18 to 55 · Women
What this study is about
Antenatal corticosteroids (ACS) reduce the risks of neonatal death and morbidities in preterm infants, such as respiratory distress syndrome. The standard of care for pregnant people at risk of preterm birth includes 2 doses of Celestone (for a total of 24 mg in Canada, or 22.8 mg in Australia) to accelerate fetal lung maturity. The investigators plan to conduct a randomized controlled trial to determine whether half the usual dose (12 mg in Canada, or 11.4 mg in Australia) of Celestone is non-inferior to the standard double doses.
Who can join (things the study team will check)
✅ You may be able to join if…
- Pregnant people, aged 18 to 55 years old, at risk of preterm birth with a singleton or twins between 22 weeks and 0 days and <34 weeks and 6 days gestation who have received only a single dose of Celestone within 24 hours
- Capable of giving informed, written consent.
🚫 You may not be able to join if…
- Contraindication to corticosteroids
- Systemic corticosteroids for medical conditions during the pregnancy (e.g. lupus, severe asthma, Covid, etc).
- Previous participation in this trial (in a previous pregnancy)
- Known severe/life-threatening fetal or pregnant patient condition (e.g. fetal congenital/chromosomal abnormality)
- Demise of one or more fetuses after 14 weeks and 0 days
Where this trial is running
- University of Calgary, Cumming School of Medicine, Calgary, Alberta, Canada
- Alberta Health Services; University of Alberta, Edmonton, Alberta, Canada
- Royal Columbian Hospital, New Westminster, British Columbia, Canada
- Fraser Health, University of British Columbia; Jim Pattison Outpatient Care and Surgery Centre, Surrey, British Columbia, Canada
- University of British Columbia; BC Women's Hospital, Vancouver, British Columbia, Canada
- Victoria General Hospital, Victoria, British Columbia, Canada
- University of Manitoba, Health Sciences Centre, Winnipeg, Manitoba, Canada
- University of Manitoba; St. Boniface General Hospital, Winnipeg, Manitoba, Canada
- Dr. Everett Chalmers Regional Hospital, Fredericton, New Brunswick, Canada
- The Moncton Hospital, Horizon Health Network, Moncton, New Brunswick, Canada
- Memorial University, Eastern Health, St. John's, Newfoundland and Labrador, Canada
- Dalhousie University; Izaak Walton Killam Health, Halifax, Nova Scotia, Canada
+ 13 more sites.
Who to contact
Sarah D McDonald, MD,MSc,FRCSC · 905-525-9140 · mcdonals@mcmaster.ca
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT05114096.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.