Surgical Ablation of AF Efficacy Trial
Recruiting now NCT05434819
Run by Population Health Research Institute · for 18 and older · All sexes
What this study is about
SAFE is an international multicentre RCT of concomitant surgical atrial fibrillation (AF) ablation in patients with paroxysmal or persistent AF undergoing cardiac surgery.
Who can join (things the study team will check)
✅ You may be able to join if…
- Age ≥ 18 years;
- Undergoing a clinically indicated cardiac surgical procedure: CABG, AVR, ascending aorta replacement, or combinations thereof;
- Documented history of paroxysmal or persistent AF
- Provide informed consent
🚫 You may not be able to join if…
- Dominant atrial arrhythmia is atrial flutter;
- Documented left atrial diameter ≥ 6 cm;
- Previous cardiac surgery requiring opening of the pericardium;
- Patients undergoing any of the following procedures:
- Heart transplant
- Complex congenital heart surgery
- Sole indication for surgery is ventricular assist device insertion
- Mitral valve repair or replacement
- Tricuspid valve repair or replacement
- Patient resides in a long-term care facility
Where this trial is running
- Hamilton General Hospital, Hamilton, Ontario, Canada
Who to contact
Richard Whitlock · 905-521-2100 · Richard.Whitlock@phri.ca
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT05434819.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.
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