Colonoscopy vs Stool Testing for Older Adults With Colon Polyps
Recruiting now NCT05612347
Run by Dartmouth-Hitchcock Medical Center · for 65 to 82 · All sexes
What this study is about
This is a multi-site comparative effectiveness randomized controlled trial (RCT) comparing annual fecal immunochemical testing (FIT) and colonoscopy for post-polypectomy surveillance among adults aged 65-82 with a history of colorectal polyps who are due for surveillance colonoscopy.
Who can join (things the study team will check)
✅ You may be able to join if…
- English or Spanish speaking
- Personal history of colorectal polyps
- Most recent colonoscopy with ≤2 non-advanced polyps
- Currently due or coming due within 12 months for colonoscopy
- Able to provide written informed consent
🚫 You may not be able to join if…
- Personal history of colorectal cancer
- Personal history of genetic syndrome with high risk for colorectal cancer (e.g. Lynch Syndrome, Familial Adenomatous Polyposis Syndrome (FAP), or Serrated Polyposis Syndrome)
- Personal history of inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease)
- Most recent colonoscopy with advanced polyp(s) or ≥3 non-advanced polyps
- Patients unlikely to benefit from polyp surveillance (e.g., history of heart disease or coronary artery disease with treatment in the last 6 months, heart failure affecting function, lung disease requiring use of home oxygen, stroke within the last 4 months, dementia affecting activities of daily living (ADL) or instrumental activities of daily living (IADL), severe liver disease requiring the use of certain medications to control fluid, confusion, or bleeding, severe kidney disease requiring dialysis, or a new cancer diagnosis within the last year)
- Patients unable to provide written informed consent
Where this trial is running
- University of Alabama Birmingham, Birmingham, Alabama, United States
- University of Arizona, Tucson, Arizona, United States
- Jennifer Moreno Department of Veterans Affairs Medical Cneter, San Diego, California, United States
- Kaiser Permanente Northern California, Walnut Creek, California, United States
- University of Colorado, Aurora, Colorado, United States
- MedStar Health, Washington D.C., District of Columbia, United States
- James A. Haley Veterans Hospital, Tampa, Florida, United States
- Northwestern Memorial Hospital, Chicago, Illinois, United States
- Richard L. Roudebush VA Medical Center, Indianapolis, Indiana, United States
- University of Michigan Health, Ann Arbor, Michigan, United States
- Henry Ford, Detroit, Michigan, United States
- Dartmouth Health, Lebanon, New Hampshire, United States
+ 10 more sites.
Who to contact
Barbie Patel, MPH · 857-4987233 · coopstudy@hitchcock.org
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT05612347.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.
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