Exercise to Improve Sleep in Parkinson's Disease

What this study is about

This study will investigate the impact of three common exercise modalities, cardiovascular, resistance, and multimodal (i.e., a combination of the previous two) training, on sleep quality and architecture in persons with Parkinson's disease (PD). Furthermore, the project will investigate whether the potential positive exercise-induced changes in sleep are associated with improvements in different quality of life (QoL)-related aspects. Participants will perform either cardiovascular training (CT), resistance training (RT), multimodal training (MT), or will be allocated to a control condition (i.e., waiting list - CON) for 12 weeks. Training will be performed three times/week. The assessments will be conducted at baseline, post-intervention, and follow-up (i.e. 8 weeks after the intervention) by assessors blinded to the participants' group allocation.

Who can join (things the study team will check)

✅ You may be able to join if…

• Persons with mild-moderate idiopathic Parkinson's Disease (Modified Hoehn \& Yahr Scale stages 0.5-3.5);
• On a stable dosage of medication during the previous month;
• Having poor sleep quality defined as a score > 15 in the PDSS-2 and/or reporting subjective sleep complaints affecting their sleep quality;

🚫 You may not be able to join if…

• Having atypical parkinsonism, dementia, stroke, or any other neurological condition;
• Presenting severe untreated obstructive sleep apnea (OSA);
• Having a Montreal Cognitive Assessment (MoCA) score <18
• Having a Beck Depression Inventory score >31;
• Having absolute contraindications to exercise;
• Having severe osteoporosis;
• Participating in an exercise or drug trial during the period of the study;
• Exceeding the physical activity levels recommended for the general population (≥150 minutes/week of moderate-intensity or ≥75 minutes/week of vigorous-intensity cardiovascular activity) and/or strengthening activities ≥2 days/week.

Where this trial is running

• Jewish Rehabilitation Hospital, Laval, Quebec, Canada
• Human Brain Control of Locomotion Laboratory, Montreal, Quebec, Canada
• Cummings Centre, Montreal, Quebec, Canada

Who to contact

Marc Roig, Ph.D. · 514-398-4400 · marc.roigpull@mcgill.ca

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT05644327.