Adjunctive Intravenous Ascorbic Acid for Advanced Non-Small Cell Lung Cancer
Recruiting now Phase 2 NCT05849129
Run by The Canadian College of Naturopathic Medicine · for 18 and older · All sexes
What this study is about
This is a two arm RCT evaluating the effect of intravenous vitamin C versus placebo in patients with incurable non-small cell lung cancer. Participants in both arms will be receiving platinum doublet chemotherapy with or without concurrent immunotherapy as standard care. We plan to enroll 90 patients over 5 years.
Who can join (things the study team will check)
✅ You may be able to join if…
- Adults (≥18 years of age) seen at TOHCC with stage IIIB or IV primary non-small cell lung cancer
- Eligible and scheduled for first line platinum-doublet chemotherapy with or without concurrent immunotherapy
🚫 You may not be able to join if…
- ECOG status greater than 2
- Previously received IVC within 6 months prior to randomization
- Biochemical deficiency in G6PD
- Estimated Glomerular Filtration Rate (eGFR) less than 45 mL/min
- Currently taking insulin or warfarin
- History of severe renal dysfunction or hemochromatosis
- Previously undergone cytotoxic chemotherapy or immunotherapy within 12 months prior to randomization
- If pregnant or planning to become pregnant: not a carrier of the gene for G6PD deficiency
- Currently taking an investigational product or participation in an investigational study within the past 30 days
- Any reason which, under the discretion of the Principal Investigator or delegate, would preclude the patient from participating
Where this trial is running
- The Ottawa Hospital, Ottawa, Ontario, Canada
Who to contact
Dugald Seely, ND, MSc · 613-792-1222 · dseely@thechi.ca
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT05849129.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.
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