NC Testing in LC & POTS
Recruiting now NCT05914649
Run by University of Calgary · for 18 to 60 · All sexes · accepts healthy volunteers
What this study is about
Patients with Postural Orthostatic Tachycardia Syndrome (POTS) and Post-Acute Sequelae of COVID (PASC, or "Long COVID") experience cognitive dysfunction. The investigators will test the hypothesis that 999 mL of IV saline will improve cognitive function in patients with POTS and Long COVID compared to placebo (50 mL of saline).
Who can join (things the study team will check)
✅ You may be able to join if…
- Patients with diagnosis of Long COVID
- SARS-COV2 test positive
- Symptoms > 12 weeks post COVID
- Subjective complaint of 'brain fog" or cognitive dysfunction
- Patients with diagnosis of Postural Orthostatic Syndrome (POTS) from the Calgary Autonomic Investigation and Management Clinic
- Subjective complaint of 'brain fog" or cognitive impairment
- Healthy participants
- Without POTS or "brain fog"
- Age 18 to 60 years
- Female and Male
- Able to give an informed consent
🚫 You may not be able to join if…
- Patients with overt causes for POTS (e.g., dehydration, prolonged bed rest)
- An inability to safely withdraw from medicine(s) that could make test interpretation difficult and impossible.
- Other factors which are in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies or an unpredictable schedule.
- Unable to give an informed consent.
Where this trial is running
- University of Calgary, Calgary, Alberta, Canada
Who to contact
Satish R Raj, MD MSCI · (403)210-6152 · autonomic.research@ucalgary.ca
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT05914649.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.
Beacon is an information tool, not medical advice. Whether a trial is right for you is a decision for you, your doctor, and the study team. Trial details come from the official registry, ClinicalTrials.gov, and may change — always confirm with the study team. Beacon collects no data about you: this page has no cookies, no accounts, and no tracking.