Adipose Tissue Storage in the Rapid Remission of Hepatic and Cardiac Metabolic Dysfunction After Bariatric Surgery

What this study is about

The present protocol aims to understand and establish whether there is a causal link between adipose tissue metabolic remodeling and Type 2 Diabetes (T2D) remission after bariatric surgery. All participants will have a bariatric surgery, divided in 2 groups: with or without T2D.

Who can join (things the study team will check)

✅ You may be able to join if…

• Aged 18 to 65
• BMI 35 kg/m2
• Diagnosed T2D - according to Diabetes Canada diagnostics criteria.
• Diagnosed non-T2D - according to Diabetes Canada diagnostics criteria.
• Women with a negative serum pregnancy test.

🚫 You may not be able to join if…

• Treatment with an oral contraceptive;
• Treatment with fibrate, thiazolidinedione, insulin, or beta-blocker, drugs that affect metabolism and cannot be stopped temporarily or which have long-lasting effects;
• Presence of overt cardiovascular disease, liver or renal failure or other uncontrolled medical conditions;
• Any other contraindication to surgery or to temporarily suspending current medications for diabetes, lipids or hypertension;
• Smoking or consumption of more than 2 alcoholic beverages per day;
• Any contraindication to MRI;
• A Diabetes Remission (DiaRem) score >8 (low probability of T2D remission);
• Having participated to a research study with exposure to radiation in the last two years before the start of the study;
• Pregnant or breastfeeding women;
• Patients weighing more than 200 kg to respect the weight and gantry limit of our MRI and PET/CT scanners.
• Being allergic to eggs

Where this trial is running

• centre de recherche du CHUS, Sherbrooke, Quebec, Canada

Who to contact

Frédérique Frisch · 1-819-346-1110 · frederique.frisch@usherbrooke.ca

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT05934409.