One-Month DAPT in CABG Patients

What this study is about

The purpose of this study is to compare the effect of ticagrelor plus low-dose aspirin versus low-dose aspirin alone in patients with chronic coronary disease undergoing coronary artery bypass grafting.

Who can join (things the study team will check)

✅ You may be able to join if…

• Age ≥18 years
• Elective first-time CABG with use of ≥1 saphenous vein graft;
• Ability to sign informed consent and comply with all study procedures, including follow-up for at least 5 years.

🚫 You may not be able to join if…

• Any indication for dual antiplatelet therapy, including
  • Acute/recent (within 1 year) ACS (NSTE-ACS or STEMI)
  • Recent PCI requiring continuation of dual antiplatelet therapy after CABG
• Current or anticipated use of oral anticoagulation;
• Paroxysmal, persistent or permanent atrial fibrillation;
• Any concomitant cardiac or non-cardiac procedure;
• Planned cardiac or non-cardiac surgery within one year;
• Preoperative end-organ dysfunction (dialysis, moderate to severe liver failure, respiratory failure), cancer or other non-cardiac comorbidity with a life expectancy <5 years;
• Inability to use the saphenous vein;
• Contraindications to the use of aspirin;
• Contraindications to the use of ticagrelor, including
  • Known hypersensitivity to ticagrelor
  • Active pathological bleeding (including, but not limited to gastrointestinal or intracranial bleeding)
  • History of intracranial hemorrhage
  • Concomitant therapy with strong CYP3A4 inhibitors (eg ketoconazole, clarithromycin, nefazodone, ritonavir, atazanavir)
• Inability to undergo coronary computed tomographic angiography (CCTA);
• Participating in another investigational device or drug study;
• Women of childbearing potential
• Any major perioperative complication including, but not limited to, stroke, TIA, MI, CABG-related bleeding (BARC type 4), sepsis.

Where this trial is running

• Englewood Hospital, Englewood, New Jersey, United States
• NewYork-Presbyterian: Queens Hospital, Flushing, New York, United States
• Weill Cornell Medicine, New York, New York, United States
• Medical University Innsbruck, Innsbruck, Innsbruck, Austria
• Medical University Graz, Graz, Austria
• Johannes Kepler University Linz, Linz, Austria
• Medical University of Vienna, Vienna, Austria
• University of Ottawa Heart Institute, Ottawa, Ontario, Canada
• Ruijin Hospital: Shanghai Jiao Tong University School of Medicine, Shanghai, China, China
• Jilin Heart Hospital, Changchun, Jilian, China
• Beijing Anzhen Hospital, Beijing, China
• Center China Fuwai Hospital, Beijing, China

+ 10 more sites.

Who to contact

Trisha Ali-Shaw · 646-962-8281 · tra2002@med.cornell.edu

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT05997693.