Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
Recruiting now Phase 2 NCT06122779
Run by Bristol-Myers Squibb · for 40 to 85 · All sexes
What this study is about
The purpose of this study is to evaluate the safety, tolerability, and exposure-response (E-R) of BMS-986435/MYK-224 in participants with symptomatic Heart Failure with Preserved Ejection Fraction (HFpEF).
Who can join (things the study team will check)
✅ You may be able to join if…
- Adult participants with stable, symptomatic HFpEF with a normal heart pumping ability.
🚫 You may not be able to join if…
- Participants must not have a known diagnosis of obstructive or genetic hypertrophic cardiomyopathy or infiltrative/storage disorder such as cardiac amyloidosis, or any other acute or serious condition that could interfere with assessments during the study or may pose a risk to the participant.
- Other protocol-defined Inclusion/Exclusion criteria apply.
Where this trial is running
- University of Alabama at Birmingham, Birmingham, Alabama, United States
- Colorado Heart and Vascular - Lakewood, Lakewood, Colorado, United States
- Ascension St. Vincent's Riverside Hospital - PPDS, Jacksonville, Florida, United States
- Local Institution - 0003, Miami, Florida, United States
- University of Miami FL Miller School of Medicine -1120 NW 14th St, Miami, Florida, United States
- Local Institution - 0014, Atlanta, Georgia, United States
- Local Institution - 0048, Atlanta, Georgia, United States
- Bluhm Cardiovascular Institute of Northwestern, Chicago, Illinois, United States
- Chicago Medical Research, LLC - Hazel Crest, Hazel Crest, Illinois, United States
- Ascension Medical Group St. Vincent - Indianapolis Heart Care, Indianapolis, Indiana, United States
- Local Institution - 0045, Indianapolis, Indiana, United States
- St. Louis Heart and Vascular, St Louis, Missouri, United States
+ 105 more sites.
Who to contact
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com · 855-907-3286 · Clinical.Trials@bms.com
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT06122779.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.
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