Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty
Recruiting now Phase 2 NCT06123715
Run by University Health Network, Toronto · for 18 and older · All sexes
What this study is about
Phase II Multicentre, pilot, parallel-group, blinded, 1:1 randomized controlled trial to determine the feasibility of conducting a larger definitive trail of using vitamin C to reduce persistent pain in patients undergoing total knee arthroplasty surgery.
Who can join (things the study team will check)
✅ You may be able to join if…
- Patients >18 years old
- Undergoing a unilateral or bilateral primary total knee arthroplasty for advanced osteoarthritis of the knee
🚫 You may not be able to join if…
- TKA for infection (septic joint), fracture, ankylosing spondylitis, lupus, or psoriatic arthritis
- History of kidney stones, acute or chronic renal failure, hemochromatosis, or glucose-6-phosphate deficiency
- Unlikely to comply with follow-up (e.g., no fixed address, plans to move out of town)
- Language difficulties that would impede valid completion of questionnaires
- Planned staged bilateral TKA
- Treating surgeon deems patient inappropriate for inclusion in trial
- Any allergy or sensitivity to milk
- Pregnant or planning to become pregnant during the study
Where this trial is running
- Sunnybrook - Holland Centre, Toronto, Ontario, Canada
- Mount Sinai Hospital, Toronto, Ontario, Canada
- Toronto Western Hospital, Toronto, Ontario, Canada
Who to contact
James Khan, MD · 416-340-4800 · James.Khan@medportal.ca
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT06123715.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.
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