KIdney aNd blooD prESsure ouTcomes in Childhood Cancer Survivors (CCS)
Recruiting now NCT06153147
Run by The Hospital for Sick Children · for Up to 19 · All sexes
What this study is about
Background: Childhood cancer survivors (CCS) are at elevated risk of chronic health conditions. Chemotherapies can cause recurrent acute kidney injury which may progress to kidney fibrosis, chronic kidney disease (CKD) or hypertension (HTN). CCS surviving to adulthood are at ≥3 times the risk (vs. non-CCS) for CKD, HTN and lower quality of life. However, the timing of CKD and HTN onset in CCS completing cancer therapy in childhood remains unclear. Guidelines provide recommendations on managing post-cancer therapy effects in CCS, but they lack specificity on kidney testing content, frequency and complications. This discord is largely due to knowledge gaps on which CCS develop CKD or HTN after cancer therapy, when outcomes occur and their severity. Existing work has shown in select patients, CKD and HTN in CCS likely begins in the first 5 years post-cancer therapy and that the burden is significant. With robust data on CKD and HTN, international CCS follow-up guidelines can be optimized to include detailed and actionable recommendations on kidney and blood pressure monitoring and treatment.
Who can join (things the study team will check)
✅ You may be able to join if…
- 3 years ± 6 months after therapy for first cancer
- Received high-risk therapy for first cancer, as defined by the Canadian Oncology Group (COG) as alkylating agents; platinums; abdominal or total body radiation; high dose methotrexate; stem cell transplant; nephrectomy; or other therapy which may be known to possibly cause late kidney and/or BP effects.
🚫 You may not be able to join if…
- Pre-cancer severe CKD and/or previous kidney transplant
- >19 years old at 3 years after cancer therapy completion
Where this trial is running
- The Hospital For Sick Children, Toronto, Ontario, Canada
Who to contact
Michael Zappitelli, MD · 4168137605 · michael.zappitelli@sickkids.ca
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT06153147.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.