StrokeNet Thrombectomy Endovascular Platform
Recruiting now NCT06289985
Run by Medical University of South Carolina · for 18 and older · All sexes
What this study is about
STEP is a Randomized, Multifactorial, Adaptive Platform trial that seeks to optimize the care of patients with acute ischemic stroke (AIS) due to large (LVO) or medium vessel occlusions (MVO).
Who can join (things the study team will check)
STEP PLATFORM INCLUSION CRITERIA: 1. Suspected diagnosis acute ischemic stroke 2. Likely causative intracranial large or medium vessel occlusion STEP PLATFORM EXCLUSION CRITERIA: 1. Proven contraindication to endovascular thrombectomy 2. Prisoners/incarcerated DOMAIN-SPECIFIC ELIGIBILITY CRITERIA: Each domain may have additional eligibility criteria. STEP EVT INDICATION EXPANSION DOMAIN INCLUSION CRITERIA: 1\. Age 18 years or older 2. Pre-stroke modified Rankin Scale score 0-2 3. Presentation to enrolling hospital within 24 hours of last known well/stroke onset 4. Able to initiate arterial puncture within 2 hours from qualifying CTA/MRA or CTP/MRP imaging \*CT/MR and qualifying CTA/MRA or CTP/MRP should be repeated if more than 120 minutes have elapsed since the imaging and randomization has not been performed. The exception is for LVO Mild deficit/Low NIHSS 0-5 for which imaging would only need to be repeated if there has been significant improvement in the NIHSS prior to randomization. 5\. Has one of the following presentations: 1. LVO patients with mild deficits/low NIHSS (must have both): 1. Mild presenting neurologic deficits - NIHSS 0-5 (Must have some focal neu…
Where this trial is running
- University of Alabama Hospital, Birmingham, Alabama, United States
- UCSD Health La Jolla, La Jolla, California, United States
- Kaiser Permanente Los Angeles Medical Center, Los Angeles, California, United States
- Ronald Reagan UCLA Medical Center, Los Angeles, California, United States
- UCSD Medical Center - Hillcrest Hospital, San Diego, California, United States
- Stanford University Medical Center, Stanford, California, United States
- Hartford Hospital, Hartford, Connecticut, United States
- Yale New Haven Hospital, New Haven, Connecticut, United States
- Jackson Memorial Hospital, Miami, Florida, United States
- Tampa General Hospital, Tampa, Florida, United States
- Grady Memorial Hospital, Atlanta, Georgia, United States
- University of Chicago Medical Center, Chicago, Illinois, United States
+ 29 more sites.
Who to contact
Jordan Elm · 843-876-1605 · elmj@musc.edu
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT06289985.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.