Is Repetitive Transcranial Magnetic Stimulation Effective in Reducing Endometriosis-associated Pain
Recruiting now NCT06333353
Run by University of Ottawa · for 18 to 60 · Women
What this study is about
The goal of this research is to improve pain outcomes for the over 500K Canadian women, girls and gender-diverse individuals who are newly diagnosed with endometriosis each year. Chronic pain that persists after interventions for endometriosis is a huge problem. There is some evidence that endometriosis-associated pain (EAP) is, at least to some extent, associated with changes in pain physiology, particularly central sensitization of pain. There is currently no effective evidence-informed intervention that addresses EAP. Yet a recent feasibility trial on a repetitive transcranial magnetic stimulation (rTMS) intervention demonstrated promising results compared to a sham intervention for reducing pain in a sample with EAP. The objectives of this trial are: 1. to evaluate the effectiveness of an rTMS intervention for pain reduction among those with recalcitrant post-operative EAP, 2. to inform on the utility of a long (10 session) vs short (5 session) protocol for pain reduction among those with recalcitrant post-operative EAP 3. to determine if any improvements in pain observed 30 days after an rTMS intervention are retained 6 months later 4. to identify physical and psychosocial mediators that impact the successful reduction of pain among patients with EAP treated using rTMS. 5. to describe patients' perceptions of and satisfaction with rTMS as an intervention for EAP.
Who can join (things the study team will check)
🚫 You may not be able to join if…
- Contra-indications to rTMS (e.g., metal/implants around the head/neck, pacemaker), history of epilepsy (history of seizures) in the family
- Pain symptoms initiated by other known causes (e.g., infections, thyroid disease, autoimmune diseases, gastrointestinal disease)
- Experience a more severe, extra-pelvic pain than that associated with endometriosis
- Pregnancy
Where this trial is running
- McLean Function Measurement Lab, Ottawa, Ontario, Canada
Who to contact
Anne-Marie MacDonald, MSc · 613-562-5800 · alake@uottawa.ca
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT06333353.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.