Fish Oil, Metformin and Heart Health in PCOS
Recruiting now Phase 1 NCT06424860
Run by University of Alberta · for 25 to 45 · Women
What this study is about
Women with Polycystic Ovary Syndrome (PCOS) have high testosterone levels which is associated with altered insulin-glucose metabolism and an adverse blood lipid profile, predisposing them to the development of Type II Diabetes and Cardiovascular Disease (CVD). This study will investigate the use of dietary fish oil supplementation as a safe and effective intervention, and as an adjunct therapy to standard of care treatment with metformin to improve heart health, blood lipids and insulin-glucose metabolism in women with PCOS, and those with PCOS and Type 2 Diabetes.
Who can join (things the study team will check)
✅ You may be able to join if…
- diagnosis of PCOS
- overweight-obese (BMI >25 kg/m2)
- elevated fasting plasma TG (>150 mg/dL)
- and/or apoB48-remnant cholesterol lipoproteins (>20 ug/ml)
- impaired insulin sensitivity (glucose 100-125 mg/dL and/or insulin >15 (uM/ml), and may be diagnosed with T2D (blood glucose >126 mg/dL).
Where this trial is running
- Human Nutrition Research Unit - Li Ka Shing Health Research Center, Edmonton, Alberta, Canada
- Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada
- University of Alberta Hospital - Division of Endocrinology, Edmonton, Alberta, Canada
Who to contact
Donna Vine, PhD · 780-492-4393 · dvine@ualberta.ca
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT06424860.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.