Pericardiotomy in Cardiac Surgery
Recruiting now NCT06486636
Run by Population Health Research Institute · for 18 and older · All sexes
What this study is about
PRINCE is an international, multicentre, randomized controlled trial of posterior pericardiotomy in patients without a history of atrial fibrillation (AF) or flutter undergoing cardiac surgery.
Who can join (things the study team will check)
✅ You may be able to join if…
- Patients greater than or equal to 18 years of age
- Requiring surgical intervention on the proximal aorta, cardiac valves, and/or coronary arteries
- Able to provide informed consent
🚫 You may not be able to join if…
- History of atrial fibrillation or flutter
- Cardiac surgery procedures not included in the inclusion criteria (planned ventricular assistance device, aortic arch, transplantation surgery)
- Prior cardiac surgery requiring opening of the pericardium
- Previous surgical instrumentation of the left pleural cavity
- Patient undergoing minimally invasive cardiac surgery
Where this trial is running
- Weill Cornell Medicine, New York, New York, United States
- Medical University Vienna, Vienna, State of Vienna, Austria
- Hamilton Health Sciences, Hamilton, Ontario, Canada
- University of Foggia, Policlinico Foggia, Foggia, Foggia, Italy
Who to contact
Richard Whitlock · 9055274322 · Richard.Whitlock@phri.ca
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT06486636.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.
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