Efficacy of NSAID vs. Steroid-NSAID Combo Post-Selective Laser Trabeculoplasty: Phase 4, Single-Center RCT
Opening soon Phase 4 NCT06498440
Run by St. Joseph's Healthcare Hamilton · for 18 and older · All sexes
What this study is about
This clinical trial, led by Dr. Enitan A. Sogbesan at the Hamilton Regional Eye Clinic, St. Joseph's Healthcare Hamilton, aims to compare the efficacy and safety of non-steroidal anti-inflammatory drug (NSAID) ketorolac alone versus a combination of ketorolac and the corticosteroid fluorometholone, and a control group receiving no postoperative treatment. The trial will evaluate these treatment strategies following Selective Laser Trabeculoplasty (SLT) in patients with open-angle glaucoma. The primary objective is to determine the most effective postoperative management strategy to reduce inflammation, improve patient comfort, and control intraocular pressure (IOP). Participants will be randomly assigned to one of the three groups, with follow-up visits scheduled at 1 hour, 1 week, 1 month, 3 months, 6 months, and 1 year post-SLT. The study's findings aim to guide clinicians in optimizing postoperative care for better patient outcomes.
Who can join (things the study team will check)
✅ You may be able to join if…
- Adults aged 18 years and older.
- Diagnosed with open-angle glaucoma.
- Intraocular pressure (IOP) greater than 16 mmHg on at least two consecutive occasions separated by one month.
- Visual acuity of 20/200 or better in at least one eye.
- Provided informed consent.
🚫 You may not be able to join if…
- Patients with any other ocular disorders or surgeries within the last six months.
- Allergy or intolerance to ketorolac or fluorometholone.
- Previous use of systemic ketorolac or fluorometholone in the past month.
- Pregnancy or breastfeeding.
- Patients who are unable to speak/understand English.
- Any condition that in the investigator's opinion would make participation not in the best interest of the patient or could prevent, limit, or confound the protocol-specified assessments.
Where this trial is running
- St. Joseph's Healthcare Hamilton, Hamilton Regional Eye Institute, Hamilton, Ontario, Canada
Who to contact
Sharan Bains, MD · (905) 573-7777 · bainss@mcmaster.ca
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT06498440.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.