Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling
Recruiting now NCT06529744
Run by University Health Network, Toronto · for 30 to 95 · All sexes
What this study is about
To develop a model to predict disease progression in a large cohort of patients across a variety of neurodegenerative diseases, including Mild Cognitive Impairment (MCI) and dementia due to any neurodegenerative disease, including Alzheimer's Disease (AD), Lewy Body Disease (LBD), Vascular Disease (VaD) and Frontotemporal lobar degeneration (FTLD).
Who can join (things the study team will check)
✅ You may be able to join if…
- Possible or probable diagnosis of MCI or early dementia
- Age 30-95
- Study partner who has some weekly contact with patient. Some of the neuropsychological assessment require collateral from close contacts to assess cognition and functioning. Since neurodegenerative diseases can be associated with reduced cognition, including reduced awareness of one's own impairments, participants will be assessed for their capacity to consent at all study visits.
- Must, in the opinion of the site investigator, be able to complete most study procedures.
🚫 You may not be able to join if…
- Participants who are not able to complete the majority of assessments in the opinion of the PI are excluded from the study. Exclusion criteria are evaluated at the site investigator's discretion; if the site investigator believes that the participant's symptoms are due to causes other than neurodegeneration, despite the presence of an exclusionary condition, the investigator may overrule the exclusion.
Where this trial is running
- Baycrest, North York, Ontario, Canada
- Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
- Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
- Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Who to contact
Claudia Clementi, HBSc · 416-603-5914 · claudia.clementi@uhn.ca
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT06529744.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.
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