A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis

What this study is about

The main purpose of this study is to determine the safety and efficacy of eltrekibart and mirikizumab in adult participants with moderately to severely active ulcerative colitis (UC).

Who can join (things the study team will check)

✅ You may be able to join if…

• Have had an established diagnosis of UC of ≥3 months in duration before baseline.
• Have moderately to severely active UC as assessed by the UC disease activity score.
• Have an inadequate response to, loss of response to, or intolerance to at least one conventional medication (including corticosteroids) or one advanced therapy (including biologics, Janus Kinase (JAK) inhibitors, or sphingosine-1-phosphate (S1P) immunomodulators).
• Are on a stable dose of certain oral UC medications (including corticosteroids).
• Must meet contraception requirements.

🚫 You may not be able to join if…

• Have received anti-interleukin (IL)-23p19 or anti-IL-12p40 antibodies in the past.
• Have experienced a thrombotic event within 24 weeks before baseline.
• Have a current diagnosis of Crohn's Disease or certain other inflammatory gastrointestinal diseases.
• Have had certain abdominal surgeries within the past 3 months or are likely to require surgery for UC during the study.
• Have a history of certain adenomas, dysplasia's, or malignancies.

Where this trial is running

• AZ Gastro Care - Chandler, Chandler, Arizona, United States
• Applied Research Center of Arkansas, Little Rock, Arkansas, United States
• Preferred Research Partners, Little Rock, Arkansas, United States
• Erick Alayo Medical Corp/Gastro SB Clinic, Chula Vista, California, United States
• Southern California GI and Liver Centers (SCLC), Coronado, California, United States
• Valley View Research, Garden Grove, California, United States
• Om Research, LLC, Lancaster, California, United States
• United Medical Doctors, Los Alamitos, California, United States
• Clinnova Research, Orange, California, United States
• Prospective Research Innovations, Rancho Cucamonga, California, United States
• Clinical Trials Management Services, LLC, Thousand Oaks, California, United States
• Om Research LLC, Victorville, California, United States

+ 195 more sites.

Who to contact

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or · 1-317-615-4559 · LillyTrials@Lilly.com

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT06598943.