Nature-based Virtual Reality Intervention for Depression in Alzheimer's Disease
Recruiting now NCT06732128
Run by Centre for Addiction and Mental Health · for 50 and older · All sexes
What this study is about
Behavioural and psychological symptoms of dementia (BPSD), such as depression affect up to 90% patients with dementia. Non-pharmacological treatment of BPSD, can be difficult to access, require caregiver support, travel, and often have long waiting lists. Virtual reality (VR) is an innovative, portable, immersive, and accessible technology which can be used in-home. More information is required on the feasibility of using VR in-home with older adults with dementia. Our study will offer a 4-week program of 15-minutes sessions, twice per week nature-based VR program for BPSD delivered in-home by virtual reality (VR). Additionally, caregivers will have the option of taking part in the study and provide feedback regarding the VR intervention. If successful, this project has the potential to prolong aging in place for individuals with BPSD, as BPSD is a significant factor in institutionalization.
Who can join (things the study team will check)
✅ You may be able to join if…
- Clinical diagnosis of mild to early-moderate stage AD (including mixed dementia with AD) using the Diagnostic and Statistical Manual of Mental Disorders, 5th Ed. Criteria
- Age of 50 years or older
- Medical stability to participate in the trial
- Patient Health Questionnaire score 5-14
- Investigator judgement on whether the participant is comfortable with technology
- Access to WiFi and a smart device for connecting on WebEx and downloading the Fitbit and Muse applications
- Have someone available to be present during all sessions
🚫 You may not be able to join if…
- Unstable medical or psychiatric condition, including substance use based on an investigator opinion
- Visual or hearing impairments that would impair participation
- Patient Health Questionnaire score 15-27 and/or score of 1 or 2 in section E question 1 of the Cornell Scale for Depression in Dementia
- Any other reason, which will make the study participation intolerable for the participant in the opinion of the study investigator
Where this trial is running
- Centre for Addictions and Mental Health (CAMH), Toronto, Ontario, Canada
Who to contact
Ashnie Sukhu, BSc · (416) 535-8501 · ashnie.sukhu@camh.ca
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT06732128.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.