A Long-term Extension Study of Dazodalibep in Participants With Sjögren's Syndrome (SS)

What this study is about

The primary objective of this study is to evaluate the long-term safety and tolerability of dazodalibep.

Who can join (things the study team will check)

✅ You may be able to join if…

• Participant has provided informed consent before initiation of any study specific activities/procedures.
• Must have been eligible to receive and have received IP (dazodalibep or placebo) and completed the study (through Week 48) in one of the phase 3 SS dazodalibep studies (HZNP-DAZ-301, or HZNP-DAZ-303).
• Must be able to receive Dose 1 of this LTE study at the Week 48 Visit (+28 days) for the prior pivotal phase 3 SS dazodalibep studies (HZNP DAZ-301, or HZNP DAZ-303).

🚫 You may not be able to join if…

• Clinically significant active infection at Day 1, in the opinion of the Investigator, including ongoing and chronic infection requiring antibiotics or antiviral medication.
• Planned participation in another clinical study with an IP or procedure during the LTE study. Other investigational procedures and participation in observational research studies while participating in this study are excluded.
• Any condition or change in health status observed or reported during the phase 3 SS studies (HZNP-DAZ-301, or HZNP-DAZ-303) that, in the opinion of the Investigator or the Sponsor, would interfere with evaluation and interpretation of participant safety or alter the risk-benefit associated with IP administration.
• Planned surgeries or hospitalizations that, in the opinion of the Investigator or the Sponsor, would interfere with evaluation and interpretation of participant safety.
• Individuals who plan to receive live (attenuated) vaccine during the LTE study.
• Female participants of childbearing potential unwilling to use protocol-specified method of contraception during treatment and for an additional 12 weeks after the last dose of investigational product.
• Female participants who are pregnant or lactating or planning to become pregnant during the study.
• Participant has known sensitivity to any of the products or components to be administered during dosing.
• Participant likely to not be available to complete all protocol-required study visits or procedures, and/or to comply with all required study procedures to the best of the participant and investigator's knowledge.
• History or evidence of any other clinically significant disorder, condition, or disease that, in the opinion of the investigator or Amgen physician, if consulted, would pose a risk to participant safety or interfere with the study evaluation.

Where this trial is running

• Arizona Arthritis & Rheumatology Associates - Avondale, Avondale, Arizona, United States
• Arizona Arthritis and Rheumatology Associates - Flagstaff - 399 S Malpais Ln, Flagstaff, Arizona, United States
• Arizona Arthritis and Rheumatology Associates - Gilbert - 3645 S Rome St, Gilbert, Arizona, United States
• Arizona Arthritis and Rheumatology Associates - Glendale - 5681 W Beverly Ln, Glendale, Arizona, United States
• Arizona Arthritis and Rheumatology Associates - Tucson - 2001 W Orange Grove Rd, Tucson, Arizona, United States
• Samy Metyas MD Inc, Covina, California, United States
• UCSD Altman Clinical and Translational Research Institute Building, La Jolla, California, United States
• Tekton Research, LLC - 2121 E Harmony Rd - PPDS, Fort Collins, Colorado, United States
• Bradenton Research Center Inc, Bradenton, Florida, United States
• Clinical Research of West Florida Inc - Clearwater, Clearwater, Florida, United States
• BayCare Medical Group Primary Care and Rheumatology - Tampa, Tampa, Florida, United States
• Tufts University School of Dental Medicine, Boston, Massachusetts, United States

+ 162 more sites.

Who to contact

Amgen Call Center · 866-572-6436 · medinfo@amgen.com

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT06747949.