Pharmacogenomics of Selective Serotonin Reuptake Inhibitor (SSRI)-Induced Behavioural Activation
Recruiting now NCT06763081
Run by University of Manitoba · for 6 to 24 · All sexes
What this study is about
The purpose of this study is to identify and validate a panel of genetic markers associated with selective serotonin reuptake inhibitors (SSRI)-induced behavioural activation in children and youth with major depressive disorder (MDD), anxiety disorders, or obsessive-compulsive disorder (OCD) that could be used clinically to reduce the incidence of this adverse event and improve health outcomes.
Who can join (things the study team will check)
✅ You may be able to join if…
- Resident of Manitoba
- Age, 6 - 24 years
- Diagnosis of major depressive disorder (MDD), anxiety disorder, or obsessive-compulsive disorder (OCD)
- Current or past history of selective serotonin reuptake inhibitor (SSRI), e.g., Citalopram [Celexa], Escitalopram [Cipralex], Fluoxetine [Prozac], Fluvoxamine [Luvox], Sertraline [Zoloft], Paroxetine [Paxil/Plaxil CR]) therapy
- [Cases Only] Have experienced behavioural side effects after taking an SSRI that resolved after reducing the dose or discontinuation of the drug
- [Controls Only] Did not experience any side effects after taking an SSRI for eight (8) continuous weeks
🚫 You may not be able to join if…
- Inability of parent/legal guardian/mature minors to give informed consent
- Inability of the child (6 - 13 years) to give informed assent
- Unwillingness of the child to provide a saliva sample for genetic analysis
- Current, past, or suspected diagnosis of attention deficit hyperactivity disorder (combined or hyperactive type), oppositional defiant disorder, conduct disorder, bipolar disorder, psychotic disorder, pervasive developmental disorder
- History of liver or bone marrow (hematopoietic cell) transplant.
Where this trial is running
- Shared Health Facilities, Winnipeg, Manitoba, Canada
- University of Manitoba College of Pharmacy, Winnipeg, Manitoba, Canada
Who to contact
Abdullah A Maruf, BPharm, MPharm, PhD · 204-318-2575 · abdullah.maruf@umanitoba.ca
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT06763081.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.