Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1

What this study is about

Clinical study of ivonescimab for first-line treatment of metastatic NSCLC patients with high PD-L1. Evaluating overall survival and progression free survival.

Who can join (things the study team will check)

✅ You may be able to join if…

• Age ≥ 18 years old at the time of enrollment
• Eastern Cooperative Oncology Group (ECOG) performance status score of 0 - 1
• Expected life expectancy ≥ 3 months
• Metastatic (Stage IV) NSCLC
• Histologically or cytologically confirmed squamous or non-squamous NSCLC
• Tumor demonstrates high PD-L1 expression ( TPS>50%) based on a 22C3 immunohistochemistry ( IHC) clinical assay approved / cleared by local health authorities.
• At least one measurable noncerebral lesion according to RECIST 1.1
• No prior systemic treatment for metastatic NSCLC.

🚫 You may not be able to join if…

• Histologic or cytopathologic evidence of the presence of small cell lung carcinoma for which first-line approved therapies are indicated. For patients with non-squamous histology, actionable driver mutation testing results are required before randomization.
• Has received any prior therapy for NSCLC in the metastatic setting.
• Concurrent enrollment in another clinical study, unless patient is enrolled in a non-interventional clinical study or is completing survival follow -up.
• Known actionable genomic alterations for which first-line approved therapies are indicated
• Symptomatic CNS metastases, CNS metastasis ≥ 1.5 cm, CNS radiation within 7 days prior to randomization, potential need for CNS radiation within the first cycle, or leptomeningeal disease
• Other prior malignancy (including previously treated NSCLC) unless the patient has undergone curative therapy with no evidence of recurrence of the disease for 3 years prior to randomization
• Active autoimmune or lung disease requiring systemic therapy
• Has pre-existing peripheral neuropathy that is ≥ Grade 2 by CTCAE version 5
• Severe infection within 4 weeks prior to randomization
• Major surgical procedures or serious trauma within 4 weeks prior to randomization
• History of noninfectious pneumonia requiring systemic corticosteroids, or current interstitial lung disease

Where this trial is running

• Clinical Study Site, Chandler, Arizona, United States
• Clinical Study Site, Phoenix, Arizona, United States
• Clinical Study Site, Hot Springs, Arkansas, United States
• Clinical Study Site, Cerritos, California, United States
• Clinical Study Site, Glendale, California, United States
• Clinical Study Site, Irvine, California, United States
• Clinical Study Site, Los Angeles, California, United States
• Clinical Study Site, Mountain View, California, United States
• Clinical Study Site, Murrieta, California, United States
• Clinical Study Site, Newport Beach, California, United States
• Clinical Study Site, Roseville, California, United States
• Clinical Study Site, Sacramento, California, United States

+ 190 more sites.

Who to contact

Summit Clinical Trial Information · 1-833-256-0522 · medicalinformation@smmttx.com

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT06767514.