The Canadian Lung Outcomes in Users of Vaping Devices Study

What this study is about

Vaping is increasingly popular with both adolescent and adult Canadians, but the long-term health impacts remain unknown. We believe that the tools we currently have to detect lung disease in people who vape may be insufficient and propose new ways to find lung injuries that may impact them over the course of their lives. These include exercise testing, new imaging techniques, and new breathing tests that will demonstrate how vaping may harm their lungs. We will use these tools in both adolescent and adult Canadians to give Canadians who vape important information on the consequences of vaping.

Who can join (things the study team will check)

✅ You may be able to join if…

• Aged ≥12 and <19 years old
• Either 1) use neither combustible cigarettes nor e-cigarettes or 2) use e-cigarettes exclusively Adult arm:
• Aged ≥19 years old
• Fall into one of the following categories: 1) use neither combustible cigarettes nor e-cigarettes; 2) use combustible cigarettes exclusively, never using e-cigarettes; 3) use e-cigarettes exclusively, never using combustible cigarettes; or 4) use both combustible cigarettes and e-cigarettes currently

🚫 You may not be able to join if…

• Contraindication to pulmonary function testing and cardiopulmonary exercise testing
• Have smoked combustible cannabis within the last month and/or have a combustible cannabis smoking history of >1 joint-year
• Have smoked combustible cigarettes within the last 6 months
• Have a physician-diagnosed chronic lung disease (such as asthma, cystic fibrosis, or bronchopulmonary dysplasia)
• Inability to provide written informed consent Adult arm:
• Contraindication to pulmonary function testing and cardiopulmonary exercise testing
• Have smoked combustible cannabis within the last month and/or have a combustible cannabis smoking history of >1 joint-year
• Currently undergoing treatment for lung cancer
• Inability to provide written informed consent No limitations will be placed on the type of e-liquids used by participants; e.g., e-cigarette users of nicotine, tetrahydrocannabinol, and cannabidiol will be all enrolled.

Where this trial is running

• University of Alberta (Clinical Sciences Building), Edmonton, Alberta, Canada
• BC Cancer Agency, Vancouver, British Columbia, Canada
• BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada
• St. Paul's Hospital, Vancouver, British Columbia, Canada
• McMaster University (Research Institute of St. Joe's Hamilton), Hamilton, Ontario, Canada
• University of Ottawa (The Ottawa Hospital General Campus), Ottawa, Ontario, Canada
• University of Toronto (The Hospital for Sick Children), Toronto, Ontario, Canada
• Université de Sherbrooke, Sherbrooke, Quebec, Canada

Who to contact

Janice Leung, MD · 604-836-0423 · janice.leung@hli.ubc.ca

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT06819969.