An Efficacy, Safety, and Tolerability Study of VX-880 in Participants With Type 1 Diabetes With a Kidney Transplant
Recruiting now Phase 3 NCT06832410
Run by Vertex Pharmaceuticals Incorporated · for 18 to 65 · All sexes
What this study is about
This study will evaluate the efficacy, safety, and tolerability of VX-880 in participants with Type 1 Diabetes (TID) with a kidney transplant.
Who can join (things the study team will check)
✅ You may be able to join if…
- Clinical history of T1D with greater than or equal to (≥)5 years of insulin dependence
- Taking a stable immunosuppression regimen of tacrolimus and mycophenolate mofetil, mycophenolate sodium, or sirolimus for at least 4 weeks
- Consistent use of continuous glucose monitor (CGM) for at least 4 weeks before Screening and willingness to use CGM for the duration of the study
🚫 You may not be able to join if…
- Prior islet cell transplant, organ transplant (other than kidney transplant), or cell therapy, except prior pancreatic graft that failed within the first 4 weeks
- Participants had >1 kidney transplant procedure Other protocol defined Inclusion/Exclusion criteria may apply.
Where this trial is running
- Perelman Center for Advanced Medicine - Endocrinology, Philadelphia, Pennsylvania, United States
- Montefiore Clinical and Translational Research Center - Endocrinology, Pittsburgh, Pennsylvania, United States
- UW University Hospital - Endocrinology, Madison, Wisconsin, United States
- Toronto General Hospital - Endocrinology, Toronto, Canada
- Vancouver General Hospital - Gordon and Leslie Diamond Health Care Centre, Vancouver, Canada
- King Abdullah International Medical Research Center (KAIMRC) - Riyadh - Endocrinology, Riyadh, Saudi Arabia
- King Faisal Specialist Hospital & Research Centre - Riyadh - Endocrinology, Riyadh, Saudi Arabia
Who to contact
Medical Information · 617-341-6777 · medicalinfo@vrtx.com
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT06832410.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.
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