Multiprofen-CC to Reduce Pain in Hand Arthritis
Recruiting now Phase 3 NCT06966206
Run by St. Joseph's Healthcare Hamilton · for 18 and older · All sexes
What this study is about
This clinical trial aims to find out if using 1 gram of Multiprofen-CC cream on the hands three times a day for 4 weeks can help reduce pain in adults with hand osteoarthritis, compared to a placebo (a cream with no active medicine). The research team will also look at how Multiprofen-CC affects hand function, opioid use, and how patients feel about their overall improvement. In addition, the research team will keep track of any side effects. Participants will: * Use both Multiprofen-CC and a placebo (a cream with no active medicine) during the study, in a random order. * Be asked to apply 1 gram of cream to their hands three times a day for 2 weeks, following the manufacturer's instructions. * Attend a visit before starting the study, after 2 weeks, and after 6 weeks. * Report any symptoms they experience during the study.
Who can join (things the study team will check)
✅ You may be able to join if…
- Adults (18+)
- Have been diagnosed with hand osteoarthritis according to American College of Rheumatology criteria
- Experience pain and/or loss of function in one or both hands that interferes with daily life
- Provide informed consent
🚫 You may not be able to join if…
- Unable to consent
- Unable or unwilling to follow study protocol
- Known allergy or contraindication to any of the study drugs or their ingredients
- Have open wounds/cuts and/or skin conditions on the hand area
- Pregnant or breastfeeding
- History of impaired kidney or liver function
- Rheumatoid or other inflammatory arthropathy
- Hand surgery within the past 6 months or planned within the study period.
- Use daily opioids (other than short acting codeine) for a chronic pain condition other than hand arthritis
Where this trial is running
- St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada
Who to contact
Breanne Flood, MSc · 905-870-1382 · bflood@stjoes.ca
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT06966206.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.