Predicting Psychotic Relapse Using Speech-Based Early Detection

What this study is about

Psychotic disorders, including schizophrenia and affective psychosis, are severe mental health conditions marked by recurrent episodes that contribute to long-term disability. Relapses, characterized by the re-emergence of psychotic symptoms after remission, are a critical factor in the progression of these disorders, increasing risks such as suicide, cognitive impairment, and unemployment. This study aims to develop a novel, speech-based digital model to predict relapses in individuals with psychosis. Building on previous research into language abnormalities in schizophrenia, the study will employ a longitudinal design across Early Psychosis Intervention (EPI) clinics in Ontario and Quebec to advance relapse prediction

Who can join (things the study team will check)

✅ You may be able to join if…

• Age must be 16 years and older
• Diagnosis must meet DSM-5 criteria for psychotic disorders, including schizophrenia, schizoaffective disorder, or related conditions
• Fluency in English or French
• Must be currently receiving treatment through an EPI program

🚫 You may not be able to join if…

• Severe comorbid speech or language disorders (e.g., aphasia)
• Primary diagnosis of non-psychotic disorders
• Inability to provide consent or complete assessments

Where this trial is running

• Robarts Research Institute, London, Ontario, Canada
• Douglas Mental Health University Institute, Montreal, Quebec, Canada
• Vitam, Québec, Quebec, Canada

Who to contact

Lena Palaniyappan, MD, PHD · 5147616131 · lena.palaniyappan@mcgill.ca

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT06978894.