A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
Recruiting now Phase 2 NCT06991257
Run by Pfizer · for 18 to 79 · All sexes
What this study is about
The purpose of this study is to learn about the safety and effects of the study medicine (PF-07328948) for the possible treatment of heart failure (HF).
Who can join (things the study team will check)
✅ You may be able to join if…
- aged 18 years to < 80 years
- clinically confirmed to have a diagnosis of heart failure for at least 3 months
- New York Heart Association Class II-IV symptoms
- left ventricular ejection fraction greater than 40%
- Kansas City Cardiomyopathy Questionnaire-23 Total Symptom Score < 85
- Six-minute walking distance greater than 75 meters
🚫 You may not be able to join if…
- Type 1 diabetes mellitus, liver cirrhosis or any condition that can possibly affect how the medicine is absorbed into the body.
- Major surgery scheduled for the duration of the study, affecting walking ability in the opinion of the study doctor.
- History of heart transplantation, or currently listed for a heart transplant, or current planned use of IV vasodilators and/ or inotropes
- Prior intolerance/known hypersensitivity to an SGLT2 inhibitor or contraindication to an SGLT2 inhibitor
Where this trial is running
- National Heart Institute, Beverly Hills, California, United States
- Orange County Research Center, Lake Forest, California, United States
- Comprehensive Cardiovascular Care, Santa Maria, California, United States
- FOMAT Medical Research, Santa Maria, California, United States
- FWD Clinical Research, Boca Raton, Florida, United States
- Jacksonville Center for Clinical Research, Jacksonville, Florida, United States
- Infinite Clinical Research, Miami, Florida, United States
- Flourish Research Acquisition, LLC dba Flourish Research - North Miami, Miami, Florida, United States
- Amavita Research Services, North Miami Beach, Florida, United States
- Clinical Site Partners, LLC dba Flourish Research, Winter Park, Florida, United States
- NMH Clinical Research Unit, Chicago, Illinois, United States
- Northwestern Memorial HealthCare - Arkes Pavilion, Chicago, Illinois, United States
+ 130 more sites.
Who to contact
Pfizer CT.gov Call Center · 1-800-718-1021 · ClinicalTrials.gov_Inquiries@pfizer.com
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT06991257.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.
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