Study of MAR001 in Adults With Elevated Triglycerides and Remnant Cholesterol

What this study is about

The primary objective of the study is to evaluate the effect of MAR001 compared to placebo on levels of TG in adults with elevated TG and RC.

Who can join (things the study team will check)

✅ You may be able to join if…

• Elevated fasting TGs and RC
• Elevated nonfasting TGs and RC
• Part A only: Fasting LDL-C ≥ 50 mg/dL (≥ 1.29 mmol/L) and ≤ 130 mg/dL (≤ 3.36 mmol/L)
• Willingness to provide informed consent and comply with the intervention and all study assessments
• Stable diet for a minimum of 3 months prior to screening and with no plans to change during screening or trial participation
• Stable drug regimen (if relevant) prior to screening visit and no planned changes after enrollment; Part B only: adjustment of lipid-lowering therapy during the diet/lifestyle run-in period is permitted

🚫 You may not be able to join if…

• Acute or chronic liver disease
• Part A only: TG concentration ≥880mg/dl; Part B only: TG concentration ≥2000 mg/dL
• History of type 1 diabetes mellitus or history of diabetic ketoacidosis
• Newly diagnosed T2DM
• Participants with known active hepatitis A, B, or C
• Uncontrolled hypothyroidism
  • Part B only: recent history of active pancreatitis
  • Part B only: genetically confirmed Familial Chylomicronemia Syndrome (FCS) diagnosis due to biallelic loss of function mutations in LPL or GPIHBP1
  • Part B only: use of ANGPTL3 and ApoC-III inhibitors
• Any condition that prevents the participant from complying with study procedures

Where this trial is running

• Marea Site 328, Anniston, Alabama, United States
• Marea Site 329, Mobile, Alabama, United States
• Marea Site 313, Little Rock, Arkansas, United States
• Marea Site 306, Hamden, Connecticut, United States
• Marea Site 302, Boca Raton, Florida, United States
• Marea Site 307, Port Saint Lucie, Florida, United States
• Marea Site 310, Columbus, Georgia, United States
• Marea Site 319, Peachtree Corners, Georgia, United States
• Marea Site 317, Park Ridge, Illinois, United States
• Marea Site 325, Springfield, Illinois, United States
• Marea Site 301, Louisville, Kentucky, United States
• Marea Site 316, Baltimore, Maryland, United States

+ 43 more sites.

Who to contact

Matty Hughes · 415-766-3610 · TYDAL_info@mareatx.com

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT07028749.