Prophylactic Proton Pump Inhibition for Esophageal Protection in Lung Radiation Therapy
Opening soon Phase 2 NCT07076914
Run by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · for 18 and older · All sexes
What this study is about
A randomized controlled trial to assess the impact of prophylactic proton pump inhibitor use to improve esophagitis in lung cancer patients undergoing radiation. Patients will be randomized into a standard of care arm or the prophylactic proton pump (daily) arm.
Who can join (things the study team will check)
✅ You may be able to join if…
- Age 18 years or older
- Willing to provide informed consent
- Eastern Cooperative Oncology Group (ECOG) performance status 0-3
- Life expectancy of at least 3 months
- Primary lung malignancy of any stage (including NSCLC and small cell lung cancer). Histologic/pathologic diagnosis is preferred, but not required.
- Receiving a prescribed dose of at least 40 Gy in 15 fractions (or equivalent). Eligible fractionations include, but are not limited to, 60 Gy in 30 fractions, 55 Gy in 20 fractions, and 40-45 Gy in 15 fractions.
- On radiation planning, at least 5 cc of esophagus is receiving at least 95% of prescription dose
🚫 You may not be able to join if…
- • Serious medical comorbidities precluding radiotherapy Note: previous radiation to the thorax is allowed, as long as the composite plan of current and prior radiation doses meet standard institutional dose constraints, in the opinion of the treating radiation oncologist.
- Use of PPI within 3 months prior to enrollment
- Allergy to PPI
- Odynophagia (painful swallowing) prior to enrollment
- Pregnant or lactating women
Where this trial is running
- London Health Sciences Centre, London, Ontario, Canada
Who to contact
David Palma · 519-685-8650 · David.Palma@lhsc.on.ca
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT07076914.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.
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