STICH3C Cardiac Magnetic Resonance Observational Study

What this study is about

STICOS will test the hypothesis that residual jeopardized myocardium, late gadolinium enhancement, and non-ischemic substrate after revascularization is associated with postoperative adverse cardiovascular events such as heart failure , readmission, or death. This study will look at whether certain heart tissue abnormalities seen on MRI scans can help predict serious health problems after heart procedures like stents or bypass surgery.

Who can join (things the study team will check)

✅ You may be able to join if…

• Men and women ≥ 18 years old
• LVEF ≤ 40% (quantified by echo, single-photon emission computed tomography [SPECT], or CMR within 2 months of enrollment)
• Prognostically important CAD: either multivessel CAD (triple vessel or double vessel CAD including left anterior descendant artery (LAD), significant coronary stenosis defined as ≥ 70% based on coronary angiography, fractional flow reserve (FFR) ≤ 0.80 or instantaneous wave-free ratio (iFR) ≤ 0.89) or left main disease (+/- other CAD) for which significant stenosis defined as > 50% based on coronary angiography, intravascular ultrasound (IVUS) minimum luminal area [MLA] value ≤ 6.0 mm2 (< 4.5 mm2 Asian descent), or equivalent optical coherence tomography (OCT) measurements.
• Planned CABG or PCI within 3 months

🚫 You may not be able to join if…

• Concomitant valve disease or other condition (e.g., LV aneurysm) requiring surgical repair or replacement
• Contraindication to CMR (i.e. magnetically activated materials), gadolinium, regadenoson/adenosine/dipyridamole
• Active neoplasm and/or severe end-organ dysfunction with expected life expectancy less than 5 years. -

Where this trial is running

• NewYork-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, United States
• New York Presbyterian - Queens, Flushing, New York, United States
• Weill Cornell Medicine/NewYork Presbyterian Hospital, New York, New York, United States
• MU Vienna Austria, Vienna, Austria
• Libin Cardiovascular Institute, Calgary, Alberta, Canada
• Universite Laval Quebec (CRIUCPQ) Canada, Québec, Canada
• Sunnybrook Health Sciences Centre, Toronto, Canada
• Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China
• Dedinje Cardiovascular Institute, Belgrade, Serbia

Who to contact

Mario Gaudino, MD, PhD, MSCE, FEBCTS, FACC · 212.746.1812 · sticos@med.cornell.edu

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT07133984.