A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)

What this study is about

Researchers are looking for more ways to treat PAH. In PAH, the blood vessels in the lungs become thick and narrow, which makes it harder for blood to flow. This causes high blood pressure in the lungs and overworks the heart. PAH can make it hard to breathe and be active. Some standard (usual) treatments for PAH can treat symptoms of PAH but do not stop PAH from getting worse. Sotatercept is a study medicine designed to treat PAH. It is a targeted therapy, which is a treatment that works on certain proteins that play a role in causing PAH. This is a long-term follow-up (LTFU) study. People who took part in certain other studies testing sotatercept for PAH may be able to join this study. The goal of this study is to learn about the long-term safety of sotatercept and if people tolerate it when taken with standard PAH treatment over a longer period of time.

Who can join (things the study team will check)

✅ You may be able to join if…

• Has completed their current respective PAH sotatercept clinical study and its requirements, and must not have discontinued early
• Is willing to adhere to the study visit schedule, and understands and will comply with all protocol requirements
• Must have the ability to understand and provide documented informed consent

🚫 You may not be able to join if…

• Did not participate in a sotatercept PAH parent study
• Missed more than the equivalent of 4 consecutive doses between the end of parent study and the start of this study.
• Presence of an ongoing serious adverse event that occurred during a PAH sotatercept clinical study that is assessed to be possibly or probably related to sotatercept
• Is a female who is pregnant or breastfeeding
• Is or has an immediate family member who is investigational site or Sponsor staff directly involved with this study
• Is currently enrolled in another investigational product study other than a sotatercept study
• Is incapacitated

Where this trial is running

• Pulmonary Associates, PA ( Site 1008), Phoenix, Arizona, United States
• Arizona Pulmonary Specialists ( Site 1010), Scottsdale, Arizona, United States
• University of Arizona ( Site 1006), Tucson, Arizona, United States
• University of California San Diego Health ( Site 1002), La Jolla, California, United States
• UC Irvine Health Medical Center ( Site 1086), Orange, California, United States
• UC Davis - Medial Center ( Site 1064), Sacramento, California, United States
• UCSF Helen Diller Medical Center at Parnassus Heights ( Site 1019), San Francisco, California, United States
• Jeffrey S. Sager, MD Medical Corporation ( Site 1060), Santa Barbara, California, United States
• Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center ( Site 1028), Torrance, California, United States
• University of Colorado Hospital ( Site 1013), Aurora, Colorado, United States
• Mayo Clinic Jacksonville ( Site 1045), Jacksonville, Florida, United States
• AdventHealth Orlando ( Site 1058), Orlando, Florida, United States

+ 115 more sites.

Who to contact

Toll Free Number · 1-888-577-8839 · Trialsites@msd.com

It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT07218029.