A Study of Solbinsiran (LY3561774) in Participants With Severe Hypertriglyceridemia
Recruiting now Phase 2 NCT07269210
Run by Eli Lilly and Company · for 18 and older · All sexes
What this study is about
The purpose of this study is to evaluate the safety and efficacy of solbinsiran in lowering triglycerides and other lipid measures compared to placebo in participants with severe hypertriglyceridemia. Participants will receive two subcutaneous injections.
Who can join (things the study team will check)
✅ You may be able to join if…
- History of fasting triglyceride levels of ≥500 milligrams per deciliter (mg/dL), based on medical history
- Fasting triglyceride level ≥500 mg/dL at two separate visits during screening (at least 7 days apart)
- Have a body mass index (BMI) within the range of 18.5 to 45.0 kilograms per square meter (kg/m2) (inclusive)
🚫 You may not be able to join if…
- Have had a major atherosclerotic cardiovascular event within the past 3 months prior to screening
- Have a known genetically confirmed diagnosis of Familial Chylomicronemia Syndrome
- Have a history of or planned treatment involving any gene editing or gene therapy modalities, including but not limited to CRISPR-based, viral vector-mediated, or other genetic modification techniques
- Have a history of chronic alcohol abuse within 3 years prior to screening
Where this trial is running
- Axsendo Clinical Research - Peak Heart & Vascular - Phoenix, Phoenix, Arizona, United States
- Synexus Clinical Research US, Inc./Orange Grove Family Practice, Tucson, Arizona, United States
- National Heart Institute, Beverly Hills, California, United States
- Ark Clinical Research, Long Beach, California, United States
- Catalina Research Institute, LLC, Montclair, California, United States
- Valley Clinical Trials, LLC dba Flourish Research, Northridge, California, United States
- CMR of Greater New Haven, LLC, Hamden, Connecticut, United States
- Northeast Research Institute - Downtown Office, Jacksonville, Florida, United States
- Novera Clinical Research, Miami, Florida, United States
- Inpatient Research Clinic, Miami Lakes, Florida, United States
- Clinical Site Partners, LLC dba Flourish Research, Winter Park, Florida, United States
- Great Lakes Clinical Trials - Ravenswood, Chicago, Illinois, United States
+ 29 more sites.
Who to contact
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or · 317-615-4559 · LillyTrials@Lilly.com
It's completely normal to call and ask questions before deciding anything. Mention the study ID: NCT07269210.
Verify everything on the official ClinicalTrials.gov record. Page updated July 2026.
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